{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:26:55Z","timestamp":1781335615101,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T00:00:00Z","timestamp":1325721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The use of ELISA testing of antibodies to desmogleins 1 and 3 (anti\u2010Dsg1 and anti\u2010Dsg3) and indirect immunofluorescence (IIF) has been strongly supported for the serologic diagnosis of pemphigus. The purpose of this study was to correlate anti\u2010Dsg1 and anti\u2010Dsg3 with IIF values, disease localization, treatment and clinical course in Greek patients with pemphigus vulgaris (PV).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A total of 54 patients with PV had ELISA serum testing for the presence and titers of anti\u2010Dsg1, anti\u2010Dsg3 and IIF. Anti\u2010Dsg1, anti\u2010Dsg3 and IIF were correlated with treatment and disease localization. For 40 patients, titers of anti\u2010Dsg1 and anti\u2010Dsg3 were assessed in relation to treatment and clinical course after 12\u2003months.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Anti\u2010Dsg3 and anti\u2010Dsg1 positivity in patients with negative IIF was 70.6% and 58.8%, respectively. Anti\u2010Dsg1 and anti\u2010Dsg3 were positive in 89.3% and 100% of patients with mucocutaneous disease, respectively, 88.9% and 66.7% of patients with skin limited disease, respectively and 52.9% and 76.5% of patients with mucosal limited disease, respectively. Both antibody titers showed significant correlation with IIF and treatment status. Improvement of clinical status was associated with significant decrease of both anti\u2010Dsg1 and anti\u2010Dsg3 after 12\u2003months.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Serum testing of anti\u2010Dsg1 and anti\u2010Dsg3 in PV patients not only provides significant correlations with IIF, treatment and disease type, but may serve as a monitoring tool for clinical course and treatment guidance.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04428.x","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T01:06:34Z","timestamp":1325811994000},"page":"430-435","source":"Crossref","is-referenced-by-count":18,"title":["Correlation of antibodies against desmogleins 1 and 3 with indirect immunofluorescence and disease status in a Greek population with pemphigus 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