{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:40:05Z","timestamp":1776440405420,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Objective\u2002<\/jats:bold> Altered lipid levels may occur in autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. However, serum lipid profiles in patients with dermatomyositis (DM) have not been investigated. Our aim was to identify lipid profiles in untreated DM patients, and to assess the relationship of the inflammatory condition of DM with lipid profiles.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> This work was designed and conducted as a case\u2010control study. Forty\u2010one DM patients and 41 age\u2010 and gender\u2010matched healthy controls were included. None of the patients had received corticosteroids or disease\u2010modifying antirheumatic drugs prior to the study. Triglyceride (TG), total cholesterol (TC), low\u2010density lipoprotein\u2010cholesterol (LDL\u2010C) and high\u2010density lipoprotein\u2010cholesterol (HDL\u2010C), C\u2010reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were assessed using standard techniques.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Twenty\u2010nine patients (70.7%) had an increase level of TG, and 41.5% had a decrease level of HDL\u2010C. The levels of HDL\u2010C in DM were significantly lower than in controls (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.01). The levels of TG, Non\u2010 HDL\u2010cholesterol and very LDL\u2010cholesterol (VLDL\u2010C) were significantly higher than in controls (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001, <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001 and <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05 respectively). The ratios of VLDL\u2010C\/LDL\u2010C, TC\/HDL\u2010C and LDL\u2010C\/HDL\u2010C were significantly higher than in controls (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001). Spearman\u2019s correlation test demonstrated that serum CRP levels correlated negatively with HDL\u2010C in DM(<jats:italic>r\u2003<\/jats:italic>=\u2003\u22120.420, <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.006).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Dyslipoproteinemia is a common feature in patients with DM that is characterized by an increase in TG and a decrease in HDL\u2010C, suggesting a high risk of atherosclerosis. Inflammation might partly account for the changes of serum lipid profiles in DM.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04437.x","type":"journal-article","created":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T19:12:52Z","timestamp":1326136372000},"page":"175-179","source":"Crossref","is-referenced-by-count":27,"title":["Lipid profiles in untreated patients with 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