{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:13:58Z","timestamp":1761110038751},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T00:00:00Z","timestamp":1329091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate the structural and functional properties of vessels in Beh\u00e7et\u2019s Disease (BD) using carotid\u2010femoral pulse wave velocity (PWV) and an echo\u2010tracking system.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> BD patients without traditional cardiovascular risk factors were selected. All BD patients performed PWV and carotid ultrasound. BD patients were divided into groups based on the presence of systemic (vascular and\/or ocular and\/or central nervous system involvement) and vascular involvement. Healthy controls age\u2010 and sex\u2010matched with the same exclusion criteria were selected.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 23 BD patients (mean age 35.0\u2003\u00b1\u20037.6\u2003years) had significantly higher PWV levels compared with controls (8.48\u2003\u00b1\u20031.14 vs. 7.53\u2003\u00b1\u20031.40\u2003m\/s, <jats:italic>P\u2003<\/jats:italic>=\u20030.017). Intima\u2010media thickness (594.87\u2003\u00b1\u2003138.61 vs. 561.08\u2003\u00b1 134.26\u2003\u03bcm, <jats:italic>P<\/jats:italic>\u2003=\u20030.371), diastolic diameter (6383.78\u2003\u00b1\u2003960.49 vs. 6447.65\u2003\u00b1\u20031159.73\u2003\u03bcm, <jats:italic>P<\/jats:italic>\u2003=\u20030.840), distension (401.95\u2003\u00b1\u2003117.72 vs. 337.91\u2003\u00b1\u2003175.36\u2003\u03bcm, <jats:italic>P<\/jats:italic>\u2003=\u20030.225) and relative distension (6.26\u2003\u00b1\u20032.83 vs. 5.42\u2003\u00b1\u20032.46\u2003\u03bcm, <jats:italic>P<\/jats:italic>\u2003=\u20030.293) were similar in both groups. The systemic disease group had significantly higher levels of PWV (8.79\u2003\u00b1\u20031.21 vs. 7.88\u2003\u00b1\u20030.72\u2003m\/s, <jats:italic>P<\/jats:italic>\u2003=\u20030.036) compared to those with exclusive mucocutaneous manifestations. BD patients with vascular involvement had similar PWV and echo\u2010tracking parameters compared to those without vascular involvement (<jats:italic>P\u2003<\/jats:italic>&gt;\u20030.05), but had higher total and LDL cholesterol levels (<jats:italic>P\u2003<\/jats:italic>=\u20030.019 and <jats:italic>P\u2003<\/jats:italic>=\u20030.012, respectively). The multivariate linear regression analysis identified triglycerides as the most important factor in increasing PWV levels (<jats:italic>P\u2003<\/jats:italic>=\u20030.001) in BD.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> PWV is more useful than carotid ultrasound in detecting structural and functional vascular damage in BD and emphasizes the role of the disease itself in promoting these alterations. Our findings also reinforce the need for rigorous control of all risk factors in BD, particularly lipoproteins.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04458.x","type":"journal-article","created":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T09:43:31Z","timestamp":1329126211000},"page":"454-459","source":"Crossref","is-referenced-by-count":17,"title":["Increased arterial stiffness assessed by pulse wave velocity in Beh\u00e7et\u2019s disease and its association with the lipid profile"],"prefix":"10.1111","volume":"27","author":[{"given":"C.A.M.","family":"Caldas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.F.","family":"Borba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.A.","family":"Bortolotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.M.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bonfa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.R.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,13]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08116.x"},{"key":"e_1_2_8_3_2","first-page":"S71","article-title":"Increased thickness of the carotid artery intima\u2010media assessed by ultrasonography in Beh\u00e7et\u2019s disease","volume":"23","author":"Keser G","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90060-3"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200301000-00006"},{"key":"e_1_2_8_6_2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0889-857X(21)01067-X","article-title":"Vasculitis in Beh\u00e7et\u2019s disease","volume":"16","author":"O\u2019Duffy JD","year":"1990","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.164.1.7998568"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2007.22.3.387"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1996.396853000.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.04.073"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.579342"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-0990-8"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.043430"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02962-X"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331970405500408"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2005.00477.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0098-8"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.09.009"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.01.057"},{"key":"e_1_2_8_20_2","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et\u2019s disease \u2013 International Study Group for Beh\u00e7et\u2019s disease","volume":"335","author":"Wechsler B","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg453"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0484-y"},{"key":"e_1_2_8_23_2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low\u2010density lipoprotein in plasma, without use of the preparative ultracentrifuge","volume":"8","author":"Fridewald WT","year":"1972","journal-title":"Clin Chem"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000202052.25238.68"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.3.485"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(97)00119-1"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2008.23.2.87"},{"key":"e_1_2_8_28_2","first-page":"341","article-title":"Vascular involvement in Beh\u00e7et\u2019s disease: arterial and venous and vessels of all sizes","volume":"19","author":"Lie JT","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(02)00290-4"},{"key":"e_1_2_8_30_2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jama.1992.03480070077035","article-title":"Secondary dyslipidemia. 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