{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:32:10Z","timestamp":1761708730540},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T00:00:00Z","timestamp":1328832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u00a0<\/jats:bold> Idiopathic guttate hypomelanosis (IGH) is an idiopathic disorder affecting a large number of people. Effective treatments are not yet available.<\/jats:p><jats:p><jats:bold>Objectives\u00a0<\/jats:bold> To investigate the efficacy of topical 0.1% tacrolimus ointment compared with placebo in the treatment of IGH.<\/jats:p><jats:p><jats:bold>Materials and methods\u00a0<\/jats:bold> Twenty\u2010six patients were included in the study. Lesions on one side of the body were selected to have a treatment with 0.1% tacrolimus ointment, whereas those on the other side served as a control with placebo ointment that had the same physical appearance. Colorimeter was used to assess skin colour at baseline and at 1, 2, 3, 4 and 6\u2003months of treatment.<\/jats:p><jats:p><jats:bold>Results\u00a0<\/jats:bold> Mean luminosity scale after adjusted for baseline from the treated side gradually decreased and reached statistical significance compared with the control group after 6\u2003months of treatment (<jats:italic>P<\/jats:italic>\u2003=\u20030.019). Physicians\u2019 improvement grading score showed that 11% of the patients demonstrated improvement of their skin lesions on the treated side after 6\u2003months\u2019 treatment.<\/jats:p><jats:p><jats:bold>Conclusion\u00a0<\/jats:bold> Topical 0.1% tacrolimus ointment appeared to be an effective and safe treatment for IGH. The improvements were best observed by colorimetry, yet, they were not statistically significant upon clinical assessments.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04462.x","type":"journal-article","created":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T16:29:35Z","timestamp":1328891375000},"page":"460-464","source":"Crossref","is-referenced-by-count":24,"title":["Topical tacrolimus significantly promotes repigmentation in idiopathic guttate hypomelanosis: a double\u2010blind, randomized, placebo\u2010controlled study"],"prefix":"10.1111","volume":"27","author":[{"given":"P.","family":"Rerknimitr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Disphanurat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Achariyakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,10]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04743.x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2005.00171.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70003-6"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.99186-8.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70273-K"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00701.x"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750010724"},{"key":"e_1_2_9_9_2","first-page":"238","article-title":"Pimecrolimus for idiopathic guttate hypomelanosis","volume":"9","author":"Asawanonda P","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04209.x"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01383.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.12.041"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01761.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1001\/archderm.1989.01670220059008","article-title":"Vitiligo and idiopathic guttate hypomelanosis. Repigmentation of skin following engraftment onto nude mice","volume":"125","author":"Gilhar A","year":"1989","journal-title":"Arch Dermatol"},{"key":"e_1_2_9_15_2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1001\/archderm.1980.01640300052016","article-title":"Idiopathic guttate hypomelanosis ultrastructural study","volume":"116","author":"Ortonne JP","year":"1980","journal-title":"Arch Dermatol"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05456.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03296.x"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.5.581"},{"key":"e_1_2_9_19_2","first-page":"2091","volume-title":"Fitzpatick\u2019s Dermatology in General Medicine","author":"Bergstrom KG","year":"2008"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07467.x"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06739.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04462.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04462.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T23:47:41Z","timestamp":1697327261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04462.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,10]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04462.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04462.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,10]]}}}