{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:25:28Z","timestamp":1789586728127,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T00:00:00Z","timestamp":1329696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Alopecia areata (AA) is regarded to be mediated by autoimmune process, and manifests as patchy non\u2010scarring hair loss with occult onset. Little is known about AA occurring later in life.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To define the characteristics of late\u2010onset AA.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Patients with first onset of AA at age 50\u2003years and above were retrospectively recruited from two separate institutes in southern and northern Taiwan. The onset age, patterns, severity, past history, serological findings and therapeutic responses were reviewed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Seventy\u2010three AA patients were enrolled, including 49 females (67%) and 24 males (33%). The onset age ranged from 50\u201378\u2003years with the median age of 57\u2003years. Multifocal lesions (41%) constituted the most common pattern and 55% of the recruited patients had a hair loss of less than 10%. Seventeen patients (23%) had co\u2010existent dermatological or systemic diseases while six patients (8%) had a history of malignancy. Among 27 patients (37%) with available laboratory data, positive anti\u2010nuclear antibody, anti\u2010microsomal antibody and anti\u2010thyroglobulin antibody was demonstrated in 26%, 40% and 30% of them, respectively. Association with personal or family history of atopy was absent. In 15 patients of follow\u2010up longer than 6\u2003months, a complete hair regrowth was found in three patients with mild disease severity.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Late\u2010onset AA is characterized by marked female predominance and milder disease activity with increasing age. The link to cancer in the old age remains to be determined. The influence of aging on the pathogenesis and prognosis of AA deserves further studies.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04467.x","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T09:27:24Z","timestamp":1329730044000},"page":"468-472","source":"Crossref","is-referenced-by-count":25,"title":["Late\u2010onset alopecia areata: A retrospective study of 73 patients from Taiwan"],"prefix":"10.1111","volume":"27","author":[{"given":"M.C.","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010C.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.Y.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.C.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.07.001"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.04.031"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu383ed"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70195-7"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0901-777"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.032"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590210048007"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb01610.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103909"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05915.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02956.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2010.08.003"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.371"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01676.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.01971.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199712150-00027"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(99)00602-8"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000181195.67084.94"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03348.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02411.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03401.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04467.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04467.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T23:47:46Z","timestamp":1697327266000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04467.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,20]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04467.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04467.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,20]]}}}