{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:21:03Z","timestamp":1793190063243,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T00:00:00Z","timestamp":1330128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Upon skin contact to irritants, interleukin\u20101 alpha (IL\u20101\u03b1) is released in the stratum corneum as a primary step of skin inflammation. Variations in the <jats:italic>IL\u20101A<\/jats:italic> gene have been shown to alter the expression of IL\u20101\u03b1. This may influence the susceptibility to skin inflammation and the development of irritant contact dermatitis (ICD).<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine effects of an <jats:italic>IL1A<\/jats:italic>\u2010889 C\/T polymorphism in view of susceptibility to develop irritant contact dermatitis.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In a case\u2013control study, 478 Caucasian patients with occupational ICD of the hands were genotyped for an <jats:italic>IL1A<\/jats:italic>\u2010889 C\/T polymorphism. Results were compared to 393 apprentices from the same high risk occupations (controls).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Trends of a protective effect of the C\u2192T transition at position <jats:italic>IL1A<\/jats:italic>\u2010889 were seen (OR\u2003=\u20030.81; 95% CI: 0.65\u20131.00). The genotype distribution for <jats:italic>IL1A<\/jats:italic>\u2010889 was 52.2% wild type (C\/C), 39.2% heterozygous (C\/T) and 8.6% homozygous for variant allele (T\/T) in patients and 46.0%, 42.7% and 11.4% in controls. Subgroup analysis, which took into account atopy status and exposure, did not reveal a significant effect of this polymorphism for an aberrant risk to acquire for ICD.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Our study indicates a possible protective effect of the <jats:italic>IL1A<\/jats:italic>\u2010889 C\/T polymorphism regarding the development of ICD.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04474.x","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T07:15:38Z","timestamp":1330154138000},"page":"1040-1043","source":"Crossref","is-referenced-by-count":23,"title":["<i>IL1A<\/i>\u2010889 C\/T gene polymorphism in irritant contact dermatitis"],"prefix":"10.1111","volume":"27","author":[{"given":"L.","family":"Landeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kezic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01345.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01669.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb08666.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03349.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246106"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00478.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750042899"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00848.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00628.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364301"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01317.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(96)00119-9"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9004-4"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1182\/blood.V73.1.104.104","article-title":"The human interleukin\u20101 alpha gene is located on the long arm of chromosome 2 at band q13","volume":"73","author":"Lafage M","year":"1989","journal-title":"Blood"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.480"},{"key":"e_1_2_5_17_2","first-page":"196","article-title":"Association analysis of interleukin gene polymorphisms in autoimmune thyroid diseases in the Tunisian population","volume":"18","author":"Kammoun\u2010Krichen M","year":"2007","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_5_18_2","first-page":"81","article-title":"Interleukin 1alpha single\u2010nucleotide polymorphism associated with systemic sclerosis","volume":"31","author":"Hutyrov\u00e1 B","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050032"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01778.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01316.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04474.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04474.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:28:32Z","timestamp":1696246112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04474.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,25]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04474.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04474.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,25]]}}}