{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:17:25Z","timestamp":1790709445061,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T00:00:00Z","timestamp":1330128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Prurigo nodularis Hyde (PN) is a highly pruritic condition due to a vicious circle of repeated itching and scratching. There are no representative clinical studies investigating comorbidities in a large collective of PN patients.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> This pilot study aimed to investigate the exact distribution of the coexisting diseases in a large representative consecutive cohort of PN patients.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A total of 108 PN patients (36.1% male; mean age of 61.5\u2003\u00b1\u200316.7\u2003years) were enrolled in the study.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In 87.0% of patients, diseases underlying PN could be established (18.5% skin disease, 7.4% systemic origin, 1.8% neurological diseases, 59.3% mixed origin). Due to several possible causative co\u2010factors, the majority of patients were classified in the group of mixed origin (59.3%). In 53.1% of these patients, at least one dermatological factor was involved in the induction of PN. Interestingly, nearly half (46.3%) of all PN patients had either an atopic predisposition or atopic dermatitis as a single cause of PN (18.5%) or as one co\u2010factor of PN of mixed origin (27.8%). Considering the different underlying diseases, there was no significant age or gender difference.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> PN does not seem to represent a characteristic symptom of one disease only. Multiple pruritogenic diseases are linked to evolution and improvement of PN upon treatment. Atopic predisposition is a major factor in nearly half of PN patients. The large collective of the present study helped detect a broad range of underlying diseases and thus to provide recommendations for rational diagnostics.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04481.x","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T07:16:23Z","timestamp":1330154183000},"page":"550-557","source":"Crossref","is-referenced-by-count":163,"title":["Prurigo as a symptom of atopic and non\u2010atopic diseases: aetiological survey in a consecutive cohort of 108 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