{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:31:25Z","timestamp":1775802685716,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T00:00:00Z","timestamp":1330041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010melanoma skin cancer (NMSC) is the most common cancer in the US, and having multiple lesions conveys substantial cost and morbidity for the individual involved. Although there are data available on risk factors for NMSC, there are currently few studies that identify specific risk factors for development of multiple NMSCs. We evaluated host risk factors for multiple NMSCs among men (Health Professionals Follow\u2010up Study) and women (Nurses\u2019 Health Study). Compared with individuals with a single NMSC, having greater number of sunburns was a risk factor for developing \u22652 NMSCs [\u226510 sunburns, cumulative relative risk (RR)\u2003=\u20031.21, 95% confidence interval (CI): 1.07\u20131.36] and a higher risk of developing \u226511 NMSCs (\u226510 sunburns, RR\u2003=\u20032.33, 95% CI: 1.57\u20133.46). Inability\u2010to\u2010tan was associated with risk of developing \u22652 NMSCs (cumulative RR\u2003=\u20031.29, 95% CI: 1.18\u20131.40) and a higher risk of developing \u226511 NMSCs (RR\u2003=\u20031.91, 95% CI: 1.50\u20132.43). Men had an increased risk of developing \u22652 NMSCs (cumulative RR\u2003=\u20031.53, 95% CI: 1.40\u20131.66). Risk of developing 2\u20134, 5\u201310 and \u226511 NMSCs increased with age. Other risk factors for developing \u22652 NMSCs included red natural hair colour (cumulative RR\u2003=\u20031.23, 95% CI: 1.07\u20131.42), family history of melanoma (cumulative RR\u2003=\u20031.15, 95% CI: 1.03\u20131.28), and having \u22656 nevi on the left arm (cumulative RR\u2003=\u20031.22, 95% CI: 1.07\u20131.40). In conclusion, physicians caring for individuals with incident NMSCs may consider paying special attention to those at highest risk for developing additional tumours, especially males and those with a history of \u226510 lifetime sunburns, by performing routine full skin examinations and counselling for aggressive photoprotection.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04483.x","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T05:43:58Z","timestamp":1330062238000},"page":"565-570","source":"Crossref","is-referenced-by-count":29,"title":["Host risk factors for the development of multiple non\u2010melanoma skin cancers"],"prefix":"10.1111","volume":"27","author":[{"given":"A.A.","family":"Qureshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.X.","family":"Wei\u2010Passanese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480240067036"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.12.1524"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.19"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1988"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603007"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11540"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011972"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.6.437"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114319"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(92)90055-U"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.155"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640178"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(79)70018-1"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1998.tb02510.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1995.tb00172.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.11.016"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371673"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.5.501"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04483.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04483.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T23:33:43Z","timestamp":1697326423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04483.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,24]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04483.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04483.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,24]]}}}