{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:34:20Z","timestamp":1761975260072},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Active chronic urticaria, identified as a mast cell\u2010 and basophil\u2010dependent inflammatory disorder of the skin is able to elicit acute phase response (APR). However, systemic inflammatory response in different types of urticaria is poorly characterized.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To determine APR pattern in a clearly defined group of patients with acute urticaria and\/or angioedema \u2013 induced by NSAIDs.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Plasma IL\u20106 and serum C\u2010reactive protein (CRP) concentrations were studied in 17 patients with NSAIDs\u2010induced acute urticaria\/angioedema (NSAIDsAU) and in 20 healthy controls. Eleven patients who used NSAIDs were presented at the emergency room with acute urticaria\/angioedema while the remaining six manifested the symptoms during the aspirin challenge test. Patients were examined in a dynamic manner: during the acute phase, and next, after subsidence of the symptoms.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> CRP and IL\u20106 concentrations increased significantly in patients with NSAIDsAU as compared with their asymptomatic period and the healthy subjects. In addition, NSAIDsAU patients showed elevated concentration of the biomarkers following aspirin provocation with the baseline values recovered in the asymptomatic period.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> These results indicate that an acute systemic inflammatory response is activated in patients with NSAIDs\u2010induced urticaria and\/or angioedema. The study supports the evidence proving that up\u2010regulation of CRP and IL\u20106 in urticaria\/angioedema does not necessarily reflect any concomitant infection or other inflammatory processes, but may be due to the disease itself.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04486.x","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T08:36:04Z","timestamp":1329813364000},"page":"1048-1052","source":"Crossref","is-referenced-by-count":20,"title":["Acute phase inflammatory markers in patients with non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs)\u2010induced acute urticaria\/angioedema and after aspirin challenge"],"prefix":"10.1111","volume":"27","author":[{"given":"A.","family":"Kasperska\u2010Zaj\u0105c","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Grzanka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Czecior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Misiolek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Rogala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Machura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.053"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03789.x"},{"key":"e_1_2_6_4_2","article-title":"Acute\u2010phase response in chronic urticaria","author":"Kasperska\u2010Zajac A","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1917"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02179.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01409.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.06.008"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02222.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03473.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03752.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2001.tb00126.x"},{"key":"e_1_2_6_14_2","article-title":"Markers of systemic inflammation in delayed pressure urticaria","author":"Kasperska\u2010Zajac A","year":"2011","journal-title":"Int J Dermatol"},{"key":"e_1_2_6_15_2","first-page":"38","article-title":"Drug\u2010induced urticaria \u2013activity of selected cytokines and acute phase proteins in plasma","volume":"58","author":"Czelej D","year":"2003","journal-title":"Ann Univ Mariae Curie Sklodowska Med"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2004.02268.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2009.07.006"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00534-X"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318921"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04486.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04486.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:28:40Z","timestamp":1696246120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04486.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,21]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04486.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04486.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,21]]}}}