{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:15:10Z","timestamp":1792628110007,"version":"4.5.0"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T00:00:00Z","timestamp":1330128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Blue light in the 400\u2013420\u2003nm range has been shown to reduce the levels of <jats:italic>Propionibacterium acnes<\/jats:italic> (<jats:italic>P. acnes<\/jats:italic>) in the skin. <jats:italic>P. acnes<\/jats:italic> has been postulated to be a critical trigger for inflammatory acne. Thus, treatment with 420\u2003nm\u2010intense pulsed light should reduce inflammatory activity in acne.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To evaluate the clinical and histological effects of 420\u2003nm\u2010intense pulsed light treatment on acne in animal model.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Inflammation acne animal model was constructed by intradermal injection of <jats:italic>P. acnes<\/jats:italic> of rat auricular. Levels of tumour necrosis factor alpha (TNF\u2010\u03b1) and matrix metalloproteinase 2 (MMP\u20102), markers of inflammation implicated in acne, were assessed in treated and untreated animals by immunohistochemistry and quantitative polymerase chain reaction (PCR).<\/jats:p><jats:p><jats:bold>Result\u2002<\/jats:bold> Treatment with 420\u2003nm intense pulsed light led to marked improvement after 6 biweekly treatments. Immunohistochemistry and PCR showed that TNF\u2010\u03b1 and MMP\u20102 levels correlated with the extent of acneiform activity and were reduced by treatment with 420\u2003nm light.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> A 420\u2010nm intense pulsed light may exert its beneficial effects on inflammatory acne by reducing the levels of <jats:italic>P. acnes<\/jats:italic> and secondarily reducing inflammation induced by the bacteria.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04487.x","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T07:21:00Z","timestamp":1330154460000},"page":"1168-1171","source":"Crossref","is-referenced-by-count":24,"title":["Effects of 420\u2010nm intense pulsed light in an acne animal model"],"prefix":"10.1111","volume":"27","author":[{"given":"X.","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010Z.","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.\u2010H.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u2010D.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.\u2010Y.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lapidoth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2003.tb00644.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/14764170410023785"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2011.630081"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12264715"},{"key":"e_1_2_6_6_2","first-page":"353","article-title":"Lasers, light and acne","volume":"71","author":"Hirsch RJ","year":"2003","journal-title":"Cutis"},{"key":"e_1_2_6_7_2","first-page":"510","article-title":"Effect of Propionibacterium acnes on the generation of TNF\u2010\u03b1, IL\u20101\u03b2 by microglia","volume":"24","author":"Chuanlong L","year":"2008","journal-title":"Chin J Cell Mol Immunol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1074-z"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701188"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04487.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04487.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:59:46Z","timestamp":1696287586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04487.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,25]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04487.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04487.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,25]]}}}