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The primary data were analyzed and collated, and the findings were formulated within the structure of a clinical guideline. The IUSTI Europe Editorial Board reviewed the draft guideline which was also posted on the web for comments which we incorporated into the final version of the guideline.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The data confirm that only surgical therapies have primary clearance rates approaching 100%. Recurrences, including new lesions at previously treated or new sites, occur after all therapies, and rates are often 20\u201330% or more. All therapies are associated with local skin reactions including itching, burning, erosions and pain.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Physicians treating patients with genital warts should develop their own treatment algorithms which include local practice and recommendations. Such patient level management protocols should incorporate medical review of cases at least every 4\u2003weeks, with switching of treatments if an inadequate response is observed. First episode patients should be offered sexually transmitted disease screening. Management should include partner notification and health promotion.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04493.x","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T13:35:32Z","timestamp":1331559332000},"source":"Crossref","is-referenced-by-count":140,"title":["2012 European guideline for the management of anogenital warts"],"prefix":"10.1111","volume":"27","author":[{"given":"C.J.N.","family":"Lacey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.C.","family":"Woodhall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wikstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/517447"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.10.3316-3322.1999"},{"key":"e_1_2_8_4_2","first-page":"1","article-title":"Natural history of genital warts","volume":"47","author":"Oriel JD","year":"1971","journal-title":"Br J Vener Dis"},{"key":"e_1_2_8_5_2","first-page":"262","article-title":"Clinical presentation of genital warts among circumcised and uncircumcised heterosexual men attending an urban STD clinic","volume":"69","author":"Cook LS","year":"1993","journal-title":"Genitourin Med"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6812.1243"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2007.029512"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1258\/0956462981921143"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2009.009012"},{"key":"e_1_2_8_10_2","unstructured":"Clinical Effectiveness Group (British Association for Sexual Health and HIV).United Kingdom National Guideline for the Management of Anogenital Warts 2007. 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