{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:00:34Z","timestamp":1792684834057,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Although halo nevus (HN) is frequently observed, the relationship between vitiligo and HN in children has rarely been investigated.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To investigate the association between HN and vitiligo in children and understand if HN\/HNi might be a risk factor for vitiligo.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Ninety\u2010eight patients with only HN\/HNi and 27 with HN\/HNi and vitiligo were investigated for number and localization of HN\/HNi, family history for HN\/HNi and vitiligo and personal and family history for autoimmune or other diseases. A follow\u2010up telephone interview was performed to investigate the evolution of HN\/HNi and the possible onset of vitiligo and\/or other diseases.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In the HN\/HNi and vitiligo group, HN\/HNi and vitiligo had started almost simultaneously in 11 children; in nine, the onset of HN\/HNi was followed by vitiligo after 6\u2003months to 5\u2003years; seven patients presented vitiligo first and HN\/HNi after 3\u20139\u2003years. Patients with associated vitiligo had, significantly more often, multiple HNi and a positive personal and\/or family history of autoimmune thyroiditis compared with those with only HN\/HNi. Follow\u2010up longer than 5\u2003years was available in 54\/98 patients with only HN\/HNi; two of them, both with multiple HNi, developed vitiligo. After follow\u2010up, multiple HNi were noticed in 18\/52 patients without vitiligo and in 9\/11 of those in whom HN\/HNi heralded vitiligo (s.s.).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In patients with multiple HNi, the risk of vitiligo and other autoimmune diseases seems to be higher than in pediatric patients with a single HN; clinicians should pay particular attention to children with multiple HNi and personal or family history of autoimmune diseases.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04504.x","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T11:56:27Z","timestamp":1331812587000},"source":"Crossref","is-referenced-by-count":29,"title":["Association of halo nevus\/i and vitiligo in childhood: a retrospective observational study"],"prefix":"10.1111","volume":"27","author":[{"given":"A.","family":"Patrizi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bentivogli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Raone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tabanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Neri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804388"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09077.x"},{"key":"e_1_2_5_4_2","first-page":"1","volume-title":"Rook\u2019s Textbook of Dermatology","author":"MacKie RM","year":"2004"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.12.1627"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051666"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00938.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0654"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12274521"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00145.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00703.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.32"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.081"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-003-0427-2"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.01030.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10154.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01171.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.11.082"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04504.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04504.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:11:18Z","timestamp":1697368278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04504.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,15]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04504.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04504.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,15]]}}}