{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:38:16Z","timestamp":1791981496346,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T00:00:00Z","timestamp":1334707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Oral 8\u2010methoxypsoralen\u2010UV\u2010A (PUVA) and Narrowband UV\u2010B (NB\u2010UVB or UVB TL\u201001) are well established treatments for chronic plaque psoriasis but there is limited evidence regarding their respective efficacy.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To prepare for evidence\u2010based recommendations concerning the practical use of oral 8\u2010methoxypsoralen\u2010UV\u2010A and Narrowband UV\u2010B in psoriasis, a systematic review to assess respective response rates, remission duration and predictive factors of efficacy was performed.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A systematic search was carried out in PubMed, Cochrane and Embase databases, using the key words \u2018Psoriasis\u2019, \u2018UVB therapy\u2019, \u2018UVA therapy\u2019 for the period from 1980 to December 2010.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The initial literature search identified 773 articles. The final selection included 29 randomized controlled trials: 18 were about the efficacy of PUVA, eight about the efficacy of NB\u2010UVB and three directly compared PUVA vs. NB\u2010UVB. The response rate defined by 75% or more improvement in PASI was 80% with PUVA vs. 70% with NB\u2010UVB. The meta\u2010analysis of the three comparative studies found a higher probability of remission at 6\u2003months with PUVA than with NB\u2010UVB [OR\u2003=\u20032.73 (95% CI 1.19\u20106.27), <jats:italic>P<\/jats:italic>\u2003=\u20030.02].<\/jats:p><jats:p>The choice of initial dose, according to skin type, the minimal erythemal dose or minimal phototoxic dose, incremental regimen and periodicity of the sessions did not appear to be predictive factors of efficacy for PUVA or NB\u2010UVB.<\/jats:p><jats:p>Despite methodological limitations in trials, the number of sessions needed for psoriasis clearance appeared to be lower with PUVA than with NB\u2010UVB (approx. 17 vs. 25, respectively).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> PUVA and NB\u2010UVB are both effective therapies in treatment of psoriasis. Our results suggest that compared with NB\u2010UVB, PUVA tends to clear psoriasis more reliably, with fewer sessions, and provides with longer lasting clearance. However, the long\u2010term safety of PUVA, especially its cutaneous carcinogenic risk, and the easier administration procedure often lead dermatologists to prefer NB\u2010UVB as first line phototherapy treatment in plaque type psoriasis.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04519.x","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T12:56:12Z","timestamp":1334753772000},"page":"11-21","source":"Crossref","is-referenced-by-count":71,"title":["Efficacy of Psoralen UV\u2010A therapy vs. Narrowband UV\u2010B therapy in chronic plaque psoriasis: a systematic literature 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