{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:11:21Z","timestamp":1771481481730,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T00:00:00Z","timestamp":1337558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\/aim\u2002<\/jats:bold> The Jarisch\u2010Herxheimer reaction (JHR) is an acute systemic event that can occur during the treatment of spirochetal infections, especially <jats:italic>Treponema pallidum<\/jats:italic> in patients with syphilis. JHR has clinical characteristics of an inflammatory reaction to antibiotic treatment and can occur with many medications as long as the antitreponemal concentrations are sufficiently high.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The incidence of and risk factors for JHR were investigated retrospectively among 1125 patients with syphilis. A total of 357 patients (32%) had secondary syphilis, 129 (12%) primary, 178 (16%) early latent, 174 (15%) late latent and 285 (25%) latent unknown duration; two patients had tertiary syphilis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Sixteen patients (1.4%) developed JHR. All JHRs occurred in patients with secondary and latent syphilis treated with penicillin.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> JHR occurred much less frequently than in previously reported studies. It is important that dermatologists recognize the clinical characteristics of JHR so that it is not misinterpreted as an allergic reaction to treatment.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04544.x","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T06:01:35Z","timestamp":1337580095000},"page":"1304-1307","source":"Crossref","is-referenced-by-count":12,"title":["Jarisch\u2010Herxheimer reaction among syphilis patients in China"],"prefix":"10.1111","volume":"27","author":[{"given":"J.","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.\u2010N.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010Y.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,21]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"132","volume":"369","author":"Chen ZQ","year":"2007","journal-title":"Syphilis in China: results of a national surveillance programme"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2005.00631.x"},{"key":"e_1_2_5_4_2","first-page":"336","article-title":"Clinical features and serologic analysis of latent syphilis","volume":"32","author":"Li J","year":"2010","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"e_1_2_5_5_2","first-page":"185","article-title":"Analysis of 1125 syphilis cases","volume":"32","author":"Li J","year":"2010","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"e_1_2_5_6_2","volume-title":"National standard of the People\u2019s Republic of China: diagnostic criteria and management of syphilis (GB 15974\u20101995)","author":"SBTS\/MOH","year":"1996"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/29.6.613"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G308"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/90.3.213"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.6.1245"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197607222950409"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.5.606"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.5.1207"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2010.010281"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04544.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04544.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:12:26Z","timestamp":1696255946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04544.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,21]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04544.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04544.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,21]]}}}