{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:21:05Z","timestamp":1764688865397},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,28]],"date-time":"2012-04-28T00:00:00Z","timestamp":1335571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u200a\/aim\u2002<\/jats:bold> Drug\u2010induced hypersensitivity syndrome (DIHS) is a severe reaction to drugs which characteristically occurs after a long latency period. In addition, human herpes virus 6 (HHV\u20106) reactivation is a characteristic finding in DIHS, which has been known to be related to disease severity. Because DIHS has generally been treated by systemic corticosteroids, the natural clinical course is not clear.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Data for patients with both DIHS and HHV\u20106 reactivation were retrospectively collected from four hospitals.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Data were collected on 12 patients ranging in age from 21 to 76\u2003years (median, 65.5). All cases had been suspected of DIHS at their initial visit, and the elevation of serum anti\u2010HHV\u20106 antibody had been confirmed (4\u2013256 times: median; 32). The culprit drugs were carbamazepine (6), salazosulfapyridine (4), mexiletine (1) and zonisamide (1). The period of latency from the first administration of the drug ranged from 15 to 50\u2003days (median, 30). All patients were treated conservatively for DIHS without systemic corticosteroids. The peaks of the patients\u2019 symptoms and laboratory findings were as follows (days from the onset of skin lesions): fever, 4\u201316 (median, 10.5); liver abnormality, 3\u201322 (median, 7.5); leukocytosis, 7\u201320 (median, 9). All patients recovered without pneumonia, myocarditis, nephritis or other systemic disease, from 7 to 37\u2003days (median, 18) after withdrawal of the drug and from 11 to 44\u2003days (median, 21) after the onset of skin lesions.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> It might be unnecessary to give systemic corticosteroids immediately to all patients suspected of having DIHS.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04547.x","type":"journal-article","created":{"date-parts":[[2012,4,28]],"date-time":"2012-04-28T06:58:57Z","timestamp":1335596337000},"page":"722-726","source":"Crossref","is-referenced-by-count":44,"title":["Clinical course of drug\u2010induced hypersensitivity syndrome treated without systemic corticosteroids"],"prefix":"10.1111","volume":"27","author":[{"given":"H.","family":"Uhara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Saiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kawachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Oguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07807.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01176.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.017"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb03795.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1113"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1108"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.145.1.67"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03718.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07704.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.198"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.1"},{"key":"e_1_2_5_13_2","first-page":"556","article-title":"Clinical features of drug\u2010induced hypersensitivity syndrome in 38 patients","volume":"20","author":"Um SJ","year":"2010","journal-title":"J Invest Allergol Clin Immunol"},{"key":"e_1_2_5_14_2","article-title":"A review of DRESS\u2010associated myocarditis","author":"Bourgeois GP","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07284.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03967.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08167.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04547.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04547.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:24:36Z","timestamp":1697369076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04547.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,28]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04547.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04547.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,28]]}}}