{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:59:44Z","timestamp":1761310784156},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T00:00:00Z","timestamp":1337731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Repigmentation as a treatment outcome in vitiligo is not assessed in a standard way, making results of clinical trials hard to compare. Different types of repigmentation assessments after punch grafting have not been compared so far.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To compare assessments of repigmentation by a digital image analysis system (DIAS) with those of clinical observers and patients after punch grafting for vitiligo.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> One vitiligo patch was selected in each patient (<jats:italic>n<\/jats:italic>\u2003=\u200321). This patch was treated with the punch grafting technique. The grade of repigmentation (%) after 3\u2003months was assessed by: (i) DIAS; (ii) 3 clinical observers ; and (iii) the patient, scoring the grade of repigmentation on photographs. Physicians and patients also evaluated the global result on a 7\u2010point scale.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> There was an almost perfect agreement between the three clinical observers and the DIAS (ICC 0.83). As expected, variation was found between the clinical observers. Patients\u2019 scores showed a moderate agreement with the DIAS (ICC 0.49) and a poor agreement with the physicians (ICC 0.28). Overall, the patients were more satisfied with the results than the physicians.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Whereas the results of the digital and clinical assessments were comparable, patients\u2019 ratings diverged. The DIAS can overcome the inevitable differences between observers, which are intrinsic to a visual grading method, and is advisable for clinical trials on vitiligo to objectively assess repigmentation in limited lesions.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04568.x","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T15:19:47Z","timestamp":1337786387000},"source":"Crossref","is-referenced-by-count":9,"title":["Digital image analysis vs. clinical assessment to evaluate repigmentation after punch grafting in vitiligo"],"prefix":"10.1111","volume":"27","author":[{"given":"M.W.","family":"Linthorst Homan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wolkerstorfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.G.","family":"Sprangers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.W.","family":"van der Veen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102030-00006"},{"key":"e_1_2_6_3_2","first-page":"CD003263","article-title":"Interventions for vitiligo","volume":"1","author":"Whitton ME","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_4_2","first-page":"150","article-title":"A new digital image analysis system useful for surface assessment of vitiligo lesions in transplantation studies","volume":"14","author":"van Geel N","year":"2004","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00411.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90292-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.11.1380"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.5.581"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.10.1203"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000092833"},{"key":"e_1_2_6_11_2","article-title":"A randomized comparison of excimer laser versus narrow\u2010band ultraviolet B phototherapy after punch grafting in stable vitiligo patients","author":"Linthorst Homan MW","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09252.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000225934"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09367.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.677"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01041181"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02577.x"},{"key":"e_1_2_6_20_2","first-page":"30","article-title":"A practical method for the estimation of vitiligo surface area: a comparison between the point counting and digital planimetry techniques","volume":"17","author":"Aydin F","year":"2007","journal-title":"Eur J Dermatol"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04568.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04568.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:13:45Z","timestamp":1697368425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04568.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,23]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04568.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04568.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,23]]}}}