{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:45:39Z","timestamp":1792899939912,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T00:00:00Z","timestamp":1340582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\/Objective\u2002<\/jats:bold>\n                    Eosinophilic annular erythema (EAE) was proposed to describe annular skin lesions associated with tissue eosinophilia, however, its relation to Well\u2019s syndrome (WS) remains a source of controversy. We studied a series of patients to increase awareness of this entity and to clarify its relation to WS.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    A multicentre study in which the clinical records, histological findings, laboratory results, therapeutic responses and follow\u2010up of 10 patients were demonstrated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    The study included seven women and three men with age ranging from 31 to 54\u2003years. The duration of the disease ranged from 3 to 28\u2003months. All patients showed involvement of trunk and extremities. Early lesions were manifested as erythematous plaques, which progressed to well\u2010developed figurate lesions and ended as large annular lesions with pigmented centre and elevated border. Flame figures were only observed in well\u2010developed and long\u2010standing lesions. Blood eosinophilia was found in all patients with different grades. Associated disorders included chronic gastritis, diabetes mellitus, chronic hepatitis\u2010C virus infection and chronic kidney disease. The disease showed chronic course with high relapse rate and resistance to various therapeutic modalities including systemic steroid alone and in combination with hydroxychloroquine and cyclosporine.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    We believe that EAE is a peculiar clinical variant in the spectrum of WS, which is characterized by a chronic course, resistance to treatment and high relapse rate. The diagnosis and evaluation of this condition need a close monitoring with repeated clinical, histological and laboratory assessment.\n                  <\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04616.x","type":"journal-article","created":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T11:10:50Z","timestamp":1340622650000},"page":"973-979","source":"Crossref","is-referenced-by-count":64,"title":["Eosinophilic annular erythema is a peculiar subtype in the spectrum of Wells syndrome: a multicentre long\u2010term follow\u2010up study"],"prefix":"10.1111","volume":"27","author":[{"given":"M.","family":"El\u2010Khalawany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Al\u2010Mutairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Shaaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.2.155"},{"key":"e_1_2_6_3_2","first-page":"46","article-title":"Recurrent granulomatous dermatitis with eosinophilia","volume":"57","author":"Wells GC","year":"1971","journal-title":"Trans St John\u2019s Hosp Dermatol Soc."},{"key":"e_1_2_6_4_2","first-page":"940","volume-title":"Cutaneous infiltrates \u2013 non\u2010lymphoid in Weedon\u2019s skin pathology","author":"Weedon D","year":"2010"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00648.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0492"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00917.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01027.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1978.tb15203.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750012685"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2010.12.009"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1981.01650030023012"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70039-X"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2008.0558"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.05.049"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2008.00456.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00164.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03792.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.20"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03675.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000245981"},{"key":"e_1_2_6_22_2","first-page":"720","article-title":"[Eosinophilic\u2010like erythema: a clinical subset of Wells\u2019 eosinophilic cellulitis responding to antimalarial drugs?]","volume":"129","author":"Dereure O","year":"2002","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1994.tb00908.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155598433610"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2001.16.5.664"},{"key":"e_1_2_6_26_2","first-page":"117","article-title":"Wells\u2019 syndrome","volume":"63","author":"Chaudhary A","year":"1997","journal-title":"Indian J Dermatol Venereol Leprol"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04616.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04616.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:27:26Z","timestamp":1696231646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04616.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,25]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04616.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04616.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,25]]}}}