{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:15:56Z","timestamp":1792656956088,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:00:00Z","timestamp":1340841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Photodynamic therapy (PDT) is an attractive modality for the treatment of BCC, based on its generally favorable efficacy, adverse effect profile and its excellent cosmetic outcome.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> The purpose of the study is to compare the efficacy and cosmetic outcome of photodynamic therapy with topical 5\u2010aminolaevulinic acid (ALA\u2010PDT) vs. simple excision surgery for superficial and nodular basal cell carcinoma (BCC).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A total of 72 patients, 32 with 48 lesions, were treated with ALA\u2010 PDT, and 40 with 46 lesions treated by excision were included in this prospective, comparative, controlled, clinical study. The patients have been followed for 16\u201337\u2003months (mean 25\u2003months). The PDT was performed in combination with 5\u2010aminolaevulinic acid twice, one month apart. Surgical excision was performed under local anesthesia with a 3\u2010mm margin, followed by histological examination. The cosmetic outcome was evaluated by the physician according to a 4\u2010point scale.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Overall 94 BCC were treated. Complete healing rates did not differ significantly between groups, <jats:italic>P<\/jats:italic>\u2003=\u20030.64 (46\/48 [95.83%] lesions treated with PDT vs. 44\/46 [95.65%] lesions with surgery). In the first 12\u2003months of follow\u2010up, 4 lesions had recurred, 2 of which were in the PDT group while 2 lesions after surgery. The mean follow\u2010up was 25\u2003months. The recurrence rate in the ALA\u2010PDT group was 4.16% vs. 4.34% in the surgery group, p\u2003=\u20030.64. The cosmetic outcome was superior for ALA\u2010PDT at all time points. At 12\u2003months, 100% lesions treated with ALA\u2010PDT had an excellent or good cosmetic outcome, according to the investigator, compared with 88.86% with surgery, <jats:italic>P<\/jats:italic>\u2003=\u20030.01.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> ALA\u2010PDT offers a similarly high efficacy, and a better cosmetic outcome than simple excision surgery in the treatment of BCC.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04619.x","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T09:13:25Z","timestamp":1340874805000},"page":"980-984","source":"Crossref","is-referenced-by-count":48,"title":["Photodynamic therapy using topical 5\u2010aminolaevulinic acid vs. surgery for basal cell carcinoma"],"prefix":"10.1111","volume":"27","author":[{"given":"R.","family":"Cosgarea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Susan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Crisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Senila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2007.00011"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2133.146.s61.2.x","article-title":"The epidemiology of skin cancer","volume":"145","author":"Diepgen TL","year":"2002","journal-title":"Br J Dermatol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02673.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.06.006"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/00015550510044136","article-title":"Photodynamic therapy for non\u2010melanoma skin cancer","volume":"85","author":"Szeimes M","year":"2005","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05940.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510032887"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07470.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.9.1131"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07833.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2006.09.008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2006.09.009"},{"issue":"3","key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/jdt.14.s3.15.22","article-title":"Clinical efficacy of methyl aminolevulinate (Metvix) photodynamic therapy","volume":"14","author":"Foley P","year":"2003","journal-title":"J Dermatolog Treat"},{"key":"e_1_2_6_15_2","first-page":"412","article-title":"Photodynamic Therapy using Metvix is as efficacious as cryotherapy in BCC, with better cosmetic results","volume":"18","author":"Basset\u2010Seguin N","year":"2004","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750010977"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04141.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2001.04407.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04619.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04619.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:27:29Z","timestamp":1696246049000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04619.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,28]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04619.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04619.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,28]]}}}