{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:14:52Z","timestamp":1761988492052},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T00:00:00Z","timestamp":1343001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Chronic lymphoedematous limbs have an increased propensity for infections and primary or secondary malignant tumours. It has been attributed to suppressed delayed\u2010type hypersensitivity measured in lymphoedemas related to Stewart\u2013Treves syndrome, Kaposi\u2019s sarcoma or breast cancer treatment. Cell\u2010mediated immunity is an effective defence mechanism against bacteria, fungi, viruses and tumour cells.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> We aimed to examine whether decongestive lymphoedema therapy could improve cell\u2010mediated immunity in breast cancer treatment\u2010related lymphoedema (BCRL).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Eight women with unilateral BCRL were included in this study. At baseline, tuberculin skin test (TST) was performed on the volar surfaces of the forearms of the affected and non\u2010affected sides using 0.5, 1 and 5 tuberculin units in the form of three consecutive injections with 3\u2010cm spaces in\u2010between, and arm volumes were measured using the Kuhnke\u2019s disc model. Decongestive lymphatic therapy was given to swollen arms in 10 consecutive working days. At the end of intensive decongestion, TST on affected side and bilateral volumetry were repeated.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Baseline test using undiluted (5 units) and fivefold diluted (1 unit) tuberculin solutions has shown significant differences (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05) between the mean sizes (11.81\u2003\u00b1\u20032.32 and 7.75\u2003\u00b1\u20031.92; 7.12\u2003\u00b1\u20031.12 and 5.12\u2003\u00b1\u20030.91 respectively) in favour to healthy arms. Post therapeutically, the mean sizes were significantly increased (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) in the dilutions of 1\u2003:\u20031 and 1\u2003:\u20035 (7.75\u2003\u00b1\u20031.92 and 10.56\u2003\u00b1\u20031.23\u2003mm, 5.12\u2003\u00b1\u20030.91 and 5.93\u2003\u00b1\u20031.74\u2003mm respectively).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Significant increase in TST sizes suggests that decongestive lymphatic therapy is able to partially restore impaired cellular immune function in BCRL.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04647.x","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T09:03:59Z","timestamp":1343034239000},"page":"1579-1582","source":"Crossref","is-referenced-by-count":13,"title":["Decongestion improves cell\u2010mediated immunity in postmastectomy arm lymphoedema: a pilot study"],"prefix":"10.1111","volume":"27","author":[{"given":"G.","family":"Szolnoky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dobozy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Kem\u00e9ny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,23]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"23","article-title":"Immune cells in peripheral lymph and skin of patients with obstructive lymphedema","volume":"23","author":"Olszewski WL","year":"1990","journal-title":"Lymphology"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120909"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03345.x"},{"key":"e_1_2_5_5_2","first-page":"489","article-title":"Syndrome de Stewart\u2010Tr\u00e9ves 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treatment\u2010related lymphedema","volume":"42","author":"Szolnoky G","year":"2009","journal-title":"Lymphology"},{"key":"e_1_2_5_15_2","first-page":"1266","article-title":"The tuberculin skin test: a comparison of ruler and calliper readings","volume":"14","author":"Geldenhuys H","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.6.2102076"}],"container-title":["Journal of the European Academy of Dermatology and 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