{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:03:31Z","timestamp":1788314611560,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> \u03b1\u2010Melanocyte\u2010stimulating hormone (\u03b1\u2010MSH) is a melanocortin peptide that increases skin pigmentation during ultraviolet light\u2010mediated tanning. As \u03b1\u2010MSH has been shown to possess anti\u2010inflammatory effects, we assessed the clinical potential of a superpotent \u03b1\u2010MSH analogue, afamelanotide (Nle<jats:sup>4<\/jats:sup>\u2010<jats:sc>d<\/jats:sc>\u2010Phe<jats:sup>7<\/jats:sup>\u2010\u03b1\u2010MSH), in patients with acne vulgaris, the most common inflammatory skin disorder.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Afamelanotide (16\u2003mg) was given in a phase II open\u2010label pilot study subcutaneously as a sustained\u2010release resorbable implant formulation to 3 patients with mild\u2010to\u2010moderate facial acne vulgaris. Evaluation included lesion count, adverse effects and patient\u2010reported outcome. Monitoring of laboratory parameters included differential blood counts, electrolytes, urine analysis, and liver and kidney function tests. Skin melanin density was measured by reflectance spectrophotometry.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The total number as well as the number of inflammatory acne lesions declined in all patients 56\u2003days after the first injection of afamelanotide. Life quality as measured by Dermatology Life Quality Index likewise improved in all 3 patients 56\u2003days after the first injection of afamelanotide. There were no adverse effects except mild and short\u2010term fatigue in one patient. All patients experienced increased pigmentation especially on the face. Clinically relevant changes in laboratory parameters were not detected.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Afamelanotide appears to have anti\u2010inflammatory effects in patients with mild\u2010to\u2010moderate acne vulgaris. Future trials are needed to confirm the anti\u2010inflammatory action of this melanocortin analogue in patients with acne vulgaris.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04658.x","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T00:19:59Z","timestamp":1343434799000},"page":"108-111","source":"Crossref","is-referenced-by-count":25,"title":["Beneficial effects of the melanocortin analogue Nle<sup>4<\/sup>\u2010D\u2010Phe<sup>7<\/sup>\u2010\u03b1\u2010MSH in acne vulgaris"],"prefix":"10.1111","volume":"28","author":[{"given":"M.","family":"B\u00f6hm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ehrchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.A.","family":"Luger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.12.1584"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00890.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.3.9666"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0710279"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80467-5"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00094.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01704.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2005.05.030"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805682"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10104.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0027"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728210903251690"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(96)00037-X"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2004.22239.x"},{"key":"e_1_2_5_16_2","first-page":"1048","article-title":"Phototherapy, photodynamic therapy and lasers in the treatment of acne","volume":"7","author":"Degitz K","year":"2009","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.67.2.233"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb03175.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04658.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04658.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:13:52Z","timestamp":1696166032000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04658.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,27]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04658.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04658.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,27]]}}}