{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:26:54Z","timestamp":1793312814049,"version":"4.5.0"},"reference-count":63,"publisher":"Wiley","issue":"s6","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Children with chronic atopic dermatitis (AD)\u2010related itch require a comprehensive treatment approach that addresses the underlying cause of pruritus, as well as symptoms and complications that extend beyond the physical domain. In small children and infants, the short\u2010term complications of quality of life disturbance and sleep dysfunction are closely associated with the course of adolescent development. In addition, the physical damage that results from uncontrolled pruritus and scratching can lead to disease chronification. Therefore, the rapid relief of acute pruritic flares, followed by the long\u2010term maintenance of symptom\u2010free skin, should be prioritized in AD treatment, in an effort to avoid the emotional, social and physical chronic manifestations described above. Alleviation of AD symptoms with fourth\u2010generation topical anti\u2010inflammatory agents like methylprednisolone aceponate is an appropriate choice of therapy for children and infants, due to its optimized therapeutic index and versatility in formulation. Especially in AD, supplemental disease management education should be considered, to address the psycho\u2010social needs of children (and their families) suffering from pruritus.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04710.x","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T08:41:49Z","timestamp":1350376909000},"page":"2-8","source":"Crossref","is-referenced-by-count":36,"title":["Atopic dermatitis in children: management of pruritus"],"prefix":"10.1111","volume":"26","author":[{"given":"U.","family":"Blume\u2010Peytavi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.11.004"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70004-4"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.03.045"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0305"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1159"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02234.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03831.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01295.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02229.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02487.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2010.05.003"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00502.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0374"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2340\/00015555-0432","article-title":"Itch intensity evaluated in the German Atopic Dermatitis Intervention Study (GADIS): correlations with quality of life, coping behaviour and SCORAD severity in 823 children","volume":"88","author":"Weisshaar E","year":"2008","journal-title":"Acta Dermatol Venereol"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0676"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0280"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27992"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1995.02170210030005"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2011.1560"},{"key":"e_1_2_7_21_2","first-page":"329","article-title":"Childhood atopic dermatitis: a measurement of quality of life and family impact","volume":"57","author":"Aziah MS","year":"2002","journal-title":"Med J Malaysia"},{"key":"e_1_2_7_22_2","first-page":"55","article-title":"The effective management of atopic dermatitis in school\u2010age children","volume":"100","author":"Ward S","year":"2004","journal-title":"Nurs Times"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2011.1.2.53"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.2.159"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02034.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05743.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01215.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsl045"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-37-59"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0933"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03942.x"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01586.x"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2011.11.008"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.200"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2009.093534"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.136"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030377"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602210103"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03850.x"},{"key":"e_1_2_7_40_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3410\/M2-39","article-title":"Recent advances in pruritus: what we have learned and where we are headed","volume":"2","author":"Yosipovitch G","year":"2010","journal-title":"F1000 Med Rep"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09308.x"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.178"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017786"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1760-08.2008"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00945.x"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.12.1522"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10227-003-0164-3"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03415.x"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10217.x"},{"key":"e_1_2_7_50_2","first-page":"361","article-title":"Second\u2010generation H1\u2010antihistamines in chronic urticaria: an evidence\u2010based review","volume":"12","author":"Kavosh ER","year":"2011","journal-title":"Am J Clin Dermatol"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1400"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705754"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701250"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P098"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-29856-8_52"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03789.x"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.3109\/09546639209092770"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07185.x"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.04.006"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.266"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02577.x"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7547.933"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0556"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2009.04.014"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04710.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04710.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1468-3083.2012.04710.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04710.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T09:23:40Z","timestamp":1693819420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04710.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,16]]},"references-count":63,"journal-issue":{"issue":"s6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04710.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04710.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,16]]}}}