{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T19:52:20Z","timestamp":1694116340225},"reference-count":6,"publisher":"Wiley","issue":"s6","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 7\u2010month\u2010old infant, with no known food allergy or intolerance, presenting with eczema lesions affecting many parts of his body, was diagnosed with infantile eczema. A skin barrier defect, due to filaggrin deficiency, was suspected. Prior treatment with emollients was not effective and produced discomfort. After twice\u2010daily application of methylprednisolone aceponate (MPA) 0.1% (Advantan<jats:sup>\u00ae<\/jats:sup>), in addition to temporary withdrawal of emollients, for 10 days. At the follow\u2010up examination, improvements in all eczema lesions, scratching behavior and sleep quality were observed, and eczema was considered almost clear and under control. Advantan was prescribed to control new flares of eczema, and heavy emollients were recommended to treat residual dryness and damage from original lesions. No side effects of Advantan were reported. In an infant with newly diagnosed eczema, Advantan was safe and effective in alleviating lesions and scratching severity and restoring sleep.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2012.04713.x","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T08:41:49Z","timestamp":1350376909000},"page":"16-17","source":"Crossref","is-referenced-by-count":2,"title":["Successful treatment of widespread eczema and sleep disruption in a 7\u2010month\u2010old infant with methylprednisolone aceponate 0.1%"],"prefix":"10.1111","volume":"26","author":[{"given":"A.","family":"Torrelo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,16]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011040"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32834cad0a"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.031"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03522.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.013"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2012.04713.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04713.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1468-3083.2012.04713.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2012.04713.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T09:23:30Z","timestamp":1693819410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2012.04713.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,16]]},"references-count":6,"journal-issue":{"issue":"s6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1468-3083.2012.04713.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04713.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,16]]}}}