{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:43:53Z","timestamp":1793119433281,"version":"4.5.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T00:00:00Z","timestamp":1451260800000},"content-version":"vor","delay-in-days":3648,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1111\/j.1469-0691.2006.01343.x","type":"journal-article","created":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T04:25:48Z","timestamp":1138076748000},"page":"3-8","source":"Crossref","is-referenced-by-count":172,"special_numbering":"S1","title":["The importance of the development of antibiotic resistance in Staphylococcus aureus"],"prefix":"10.1016","volume":"12","author":[{"given":"G.C.","family":"Schito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 2","key":"10.1111\/j.1469-0691.2006.01343.x_bib1","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1086\/320184","volume":"32","author":"Diekema","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib2","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1172\/JCI18535","article-title":"Antimicrobial resistance: the example of Staphylococcus aureus","volume":"111","author":"Lowy","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib3","author":"World Health Organization"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib4","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1128\/JCM.38.2.866-869.2000","article-title":"Heterogeneous vancomycin resistance in methicillin\u2010resistant Staphylococcus aureus strains isolated in a large Italian hospital","volume":"38","author":"Marchese","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0891-5520(05)70392-5","article-title":"Antimicrobial resistance in staphylococci. Epidemiology, molecular mechanisms, and clinical relevance","volume":"11","author":"Maranan","year":"1997","journal-title":"Infect Dis Clin North Am"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib6","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1128\/AAC.42.11.3024","article-title":"Characterization of erythromycin\u2010resistant isolates of Staphylococcus aureus recovered in the United States from 1958 through 1969","volume":"42","author":"Nicola","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1128\/CMR.3.1.13","article-title":"Discovery and development of new antimicrobial agents","volume":"3","author":"Gootz","year":"1990","journal-title":"Clin Microbiol Rev"},{"issue":"suppl 3","key":"10.1111\/j.1469-0691.2006.01343.x_bib8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1469-0691.2005.01140.x","article-title":"Biological counterstrike: antibiotic resistance mechanisms of Gram\u2010positive cocci","volume":"11","author":"Woodford","year":"2005","journal-title":"Clin Microbiol Infect"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/bmj.1.5219.124-a","article-title":"\u2018Celbenin\u2019\u2010resistant staphylococci","volume":"1","author":"Jevons","year":"1961","journal-title":"BMJ"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/mdr.1996.2.377","article-title":"Ubiquitous presence of a mecA homologue in natural isolates of Staphylococcus sciuri","volume":"2","author":"Couto","year":"1996","journal-title":"Microb Drug Resist"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib11","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.3201\/eid1009.040069","article-title":"Methicillin\u2010resistant Staphylococcus aureus in Europe, 1999\u20132002","volume":"10","author":"Tiemersma","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3201\/eid0902.020233","article-title":"Elimination of epidemic methicillin\u2010resistant Staphylococcus aureus from a university hospital and district institutions, Finland","volume":"9","author":"Kotilainen","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1086\/345476","article-title":"Comparison of mortality associated with methicillin\u2010resistant and methicillin\u2010susceptible Staphylococcus aureus bacteremia: a meta\u2010analysis","volume":"36","author":"Cosgrove","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib14","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/clinids\/21.6.1417","article-title":"Mortality associated with nosocomial bacteremia due to methicillin\u2010resistant Staphylococcus aureus","volume":"21","author":"Romero\u2010Vivas","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib15","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1086\/313440","article-title":"Bacteremic pneumonia due to Staphylococcus aureus: a comparison of disease caused by methicillin\u2010resistant and methicillin\u2010susceptible organisms","volume":"29","author":"Gonzalez","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib16","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1128\/AAC.47.12.3926-3934.2003","article-title":"Evolutionary models of the emergence of methicillin\u2010resistant Staphylococcus aureus","volume":"47","author":"Robinson","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib17","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1086\/520437","article-title":"Community\u2010acquired methicillin\u2010resistant Staphylococcus aureus in hospitalized adults and children without known risk factors","volume":"29","author":"Gorak","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib18","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMoa042683","article-title":"Necrotizing fasciitis caused by community\u2010associated methicillin\u2010resistant Staphylococcus aureus in Los Angeles","volume":"352","author":"Miller","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1086\/345436","article-title":"Community\u2010acquired methicillin\u2010resistant Staphylococcus aureus: a meta\u2010analysis of prevalence and risk factors","volume":"36","author":"Salgado","year":"2003","journal-title":"Clin Infect Dis"},{"issue":"suppl 1","key":"10.1111\/j.1469-0691.2006.01343.x_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1469-0691.2006.01341.x","article-title":"Community\u2010acquired MRSA: current perspectives","volume":"12","author":"Klutymans\u2010VandenBergh","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib21","first-page":"565","article-title":"Staphylococcus aureus resistant to vancomycin\u2014United States, 2002","volume":"51","author":"Sievert","year":"2002","journal-title":"MMWR"},{"key":"10.1111\/j.1469-0691.2006.01343.x_bib22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1086\/381202","article-title":"Treatment outcomes for serious infections caused by methicillin\u2010resistant Staphylococcus aureus with reduced vancomycin susceptibility","volume":"38","author":"Howden","year":"2004","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X15600829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X15600829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T03:31:58Z","timestamp":1586662318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X15600829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":22,"alternative-id":["S1198743X15600829"],"URL":"https:\/\/doi.org\/10.1111\/j.1469-0691.2006.01343.x","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]}}}