{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:05:44Z","timestamp":1793138744830,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T00:00:00Z","timestamp":1419379200000},"content-version":"vor","delay-in-days":1606,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1111\/j.1469-0691.2009.03037.x","type":"journal-article","created":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T02:22:32Z","timestamp":1251944552000},"page":"1207-1212","source":"Crossref","is-referenced-by-count":43,"title":["An open randomized controlled trial of desmopressin and pulse dexamethasone as adjunct therapy in patients with pulmonary involvement associated with severe leptospirosis"],"prefix":"10.1016","volume":"16","author":[{"given":"K.","family":"Niwattayakul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kaewtasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chueasuwanchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hoontrakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chareonwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Suttinont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Phimda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Chierakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Silpasakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Suputtamongkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1469-0691.2009.03037.x_bib1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1473-3099(03)00830-2","article-title":"Leptospirosis: a zoonotic disease of global importance","volume":"3","author":"Bhati","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib2","first-page":"94","article-title":"Clinico-epidemiological study of hospitalized cases of severe leptospirosis","volume":"109","author":"Singh","year":"1999","journal-title":"Indian J Med Res"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib3","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1086\/313501","article-title":"Acute lung injury in leptospirosis: clinical and laboratory features, outcome, and factors associated with mortality","volume":"29","author":"Marotto","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0035-9203(00)90445-0","article-title":"Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles","volume":"94","author":"Yersin","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib5","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3201\/eid0809.010499","article-title":"Lethal leptospiral pulmonary hemorrhage: an emerging disease in Buenos Aires, Argentina","volume":"8","author":"Seijo","year":"2002","journal-title":"Emerg Infect Dis"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1201-9712(02)90137-2","article-title":"Prognostic factors of death in leptospirosis: a prospective cohort study in Khon Kaen, Thailand","volume":"6","author":"Panaphut","year":"2002","journal-title":"Int J Infect Dis"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1378\/chest.123.2.639","article-title":"Leptospirosis presenting as diffuse alveolar hemorrhage: case report and literature review","volume":"123","author":"Luks","year":"2003","journal-title":"Chest"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib8","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0002-9440(10)63198-7","article-title":"Alveolar septal deposition of immunoglobulin and complement parallels pulmonary hemorrhage in a guinea pig model of severe pulmonary leptospirosis","volume":"164","author":"Nally","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib9","first-page":"759","article-title":"Nitric oxide production and immunoglobulin deposition in leptospiral hemorrhagic respiratory failure","volume":"104","author":"Yang","year":"2005","journal-title":"J Formos Med Assoc"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib10","first-page":"901","article-title":"Role of glucocorticoid pulse therapy in pulmonary involvement in leptospirosis","volume":"49","author":"Trivedi","year":"2001","journal-title":"J Assoc Physicians India"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib11","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/pgmj.2005.044255","article-title":"Pulmonary leptospirosis: an excellent response to bolus methyl prednisolone","volume":"82","author":"Shenoy","year":"2006","journal-title":"Postgrad Med J"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib12","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1182\/blood.V90.7.2515","article-title":"Desmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years","volume":"90","author":"Mannucci","year":"1997","journal-title":"Blood"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib13","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1164\/rccm.200205-450CR","article-title":"Desmopressin therapy for massive hemoptysis associated with severe leptospirosis","volume":"167","author":"Pea","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib14","series-title":"Leptospira and leptospirosis","year":"1999"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib15","first-page":"568573","article-title":"Detection of pathogenic leptospires in animals by PCR based on lipL21 and lipL32 genes","volume":"45","author":"Cheemaa","year":"2007","journal-title":"Indian J Exp Biol"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib16","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1128\/JCM.35.11.2715-2727.1997","article-title":"Laboratory diagnosis of rickettsioses: current approaches to diagnosis of old and new rickettsial diseases","volume":"35","author":"La Scola","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1086\/427110","article-title":"Clinical spectrum of pulmonary involvement in leptospirosis in a region of endemicity, with quantitation of leptospiral burden","volume":"40","author":"Segura","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib18","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nature01597","article-title":"Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing","volume":"422","author":"Ren","year":"2003","journal-title":"Nature"},{"key":"10.1111\/j.1469-0691.2009.03037.x_bib19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1172\/JCI9516","article-title":"Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP","volume":"106","author":"Kaufmann","year":"2000","journal-title":"J Clin Invest"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14642208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14642208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:10:52Z","timestamp":1590106252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X14642208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S1198743X14642208"],"URL":"https:\/\/doi.org\/10.1111\/j.1469-0691.2009.03037.x","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}