{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:33:19Z","timestamp":1793827999711,"version":"4.6.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T00:00:00Z","timestamp":1417219200000},"content-version":"vor","delay-in-days":1094,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1111\/j.1469-0691.2011.03514.x","type":"journal-article","created":{"date-parts":[[2011,3,23]],"date-time":"2011-03-23T12:18:49Z","timestamp":1300882729000},"page":"1798-1803","source":"Crossref","is-referenced-by-count":369,"title":["Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment"],"prefix":"10.1016","volume":"17","author":[{"given":"O.","family":"Zarkotou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pournaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Tselioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Dragoumanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Pitiriga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ranellou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Prekates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Themeli-Digalaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tsakris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1469-0691.2011.03514.x_bib1","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1093\/jac\/dkp255","article-title":"Has the era of untreatable infections arrived?","volume":"64","author":"Livermore","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1469-0691.2009.03115.x","article-title":"Controlling the spread of carbapenemase\u2010producing Gram\u2010negatives: therapeutic approach and infection control","volume":"16","author":"Carmeli","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1469-0691.2009.03114.x","article-title":"The emerging threat of acquired carbapenemases in Gram\u2010negative bacteria","volume":"16","author":"Cornaglia","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1473-3099(09)70054-4","article-title":"The real threat ofKlebsiella pneumoniae carbapenemase\u2010producing bacteria","volume":"9","author":"Nordmann","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib5","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/jac\/dkp207","article-title":"Clonal spread of KPC\u20102 carbapenemase\u2010producingKlebsiella pneumoniae strains in Greece","volume":"64","author":"Pournaras","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib6","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1086\/649865","article-title":"An outbreak of infection due to beta\u2010lactamaseKlebsiella pneumoniae carbapenemase 2\u2010producingK.\u00a0pneumoniae in a Greek University Hospital: molecular characterization, epidemiology, and outcomes","volume":"50","author":"Souli","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib7","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1128\/JCM.43.10.5344-5347.2005","article-title":"Outbreaks in distinct regions due to a singleKlebsiella pneumoniae clone carrying ablaVIM\u20101 metallo\u2010beta\u2010lactamase gene","volume":"43","author":"Ikonomidis","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib8","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1086\/648451","article-title":"Risk factors and clinical impact ofKlebsiella pneumoniae carbapenemase\u2010producingK.\u00a0pneumoniae","volume":"30","author":"Gasink","year":"2009","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib9","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1093\/jac\/dkq108","article-title":"Detection and treatment options forKlebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug\u2010resistant infections","volume":"65","author":"Hirsch","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0196-6553(88)90053-3","article-title":"CDC definitions for nosocomial infections","volume":"16","author":"Garner","year":"1988","journal-title":"Am J Infect Control"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib12","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1186\/cc5006","article-title":"Reappraisal ofPseudomonas aeruginosa hospital\u2010acquired pneumonia mortality in the era of metallo\u2010\u03b2\u2010lactamase\u2010mediated multidrug resistance: a prospective observational study","volume":"10","author":"Zavascki","year":"2006","journal-title":"Crit Care"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib13","series-title":"Performance standards for antimicrobial susceptibility testing, 20th informational supplement. CLSI document. M100\u2010S20\u2010U","author":"Clinical and Laboratory Standards Institute","year":"2010"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib14","series-title":"Tygacil (tigecycline IV) [package insert]","author":"Wyeth Pharmaceuticals Inc","year":"2005"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib15","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1128\/JCM.00879-06","article-title":"Phenotypic detection of carbapenem\u2010susceptible metallo\u2010\u03b2\u2010lactamase\u2010producing gram\u2010negative bacilli in the clinical laboratory","volume":"44","author":"Franklin","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib16","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/JCM.01922-08","article-title":"Evaluation of boronic acid disk tests for differentiating KPC\u2010possessingKlebsiella pneumoniae isolates in the clinical laboratory","volume":"47","author":"Tsakris","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib17","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/JCM.01988-09","article-title":"Direct ertapenem disk screening method for identification of KPC\u2010producingKlebsiella pneumoniae andEscherichia coli in surveillance swab specimens","volume":"48","author":"Lolans","year":"2010","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib18","series-title":"Performance 343 standards for antimicrobial susceptibility testing","author":"Clinical and Laboratory Standards Instiitute","year":"2010"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib19","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1086\/590661","article-title":"Use of active surveillance cultures to detect asymptomatic colonization with carbapenem\u2010resistantKlebsiella pneumoniae in intensive care unit patients","volume":"29","author":"Calfee","year":"2008","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib20","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1001\/archinte.165.12.1430","article-title":"Rapid spread of carbapenem\u2010resistantKlebsiella pneumoniae in New York City","volume":"165","author":"Bratu","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib21","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1128\/AAC.01020-07","article-title":"Predictors of carbapenem\u2010resistantKlebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality","volume":"52","author":"Schwaber","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib22","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1128\/AAC.48.12.4793-4799.2004","article-title":"Outbreak ofKlebsiella pneumoniae producing a new carbapenem\u2010hydrolyzing class A \u03b2\u2010lactamase, KPC\u20103, in a New York Medical Center","volume":"48","author":"Woodford","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib23","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1086\/592412","article-title":"Outcomes of carbapenem\u2010resistantKlebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies","volume":"29","author":"Patel","year":"2008","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijantimicag.2010.10.031","article-title":"Activity of tigecycline alone and in combination with colistin and meropenem againstKlebsiella pneumoniae carbapenemase (KPC)\u2010producing Enterobacteriaceae strains by time\u2010kill assay","volume":"37","author":"Pournaras","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib25","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1128\/JCM.02301-09","article-title":"Risk factors and outcomes associated with acquisition of colistin\u2010resistant KPC\u2010producingKlebsiella pneumoniae: a matched case\u2010control study","volume":"48","author":"Zarkotou","year":"2010","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1469-0691.2011.03514.x_bib26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.diagmicrobio.2009.02.004","article-title":"Clinical outcomes of patients withKlebsiella pneumoniae carbapenemase\u2010producingK.\u00a0pneumoniae after treatment with imipenem or meropenem","volume":"64","author":"Weisenberg","year":"2009","journal-title":"Diagn Microbiol Infect Dis"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14619248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14619248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T22:54:45Z","timestamp":1543877685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X14619248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1198743X14619248"],"URL":"https:\/\/doi.org\/10.1111\/j.1469-0691.2011.03514.x","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}