{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T17:07:07Z","timestamp":1756573627694},"reference-count":22,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T00:00:00Z","timestamp":1419379200000},"content-version":"vor","delay-in-days":906,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1111\/j.1469-0691.2012.03886.x","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T10:12:33Z","timestamp":1334225553000},"page":"E254-E258","source":"Crossref","is-referenced-by-count":14,"title":["Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies"],"prefix":"10.1016","volume":"18","author":[{"given":"M.S.","family":"Ramirez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Hujer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.S.G.","family":"Chain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.A.","family":"Bonomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.E.","family":"Tolmasky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/j.1469-0691.2012.03886.x_bib1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1473-3099(09)70054-4","article-title":"The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria","volume":"9","author":"Nordmann","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10096-011-1319-6","article-title":"Molecular analysis of population structure and antibiotic resistance of Klebsiella isolates from a three-year surveillance program in Florence hospitals, Italy","volume":"31","author":"Donnarumma","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1128\/AAC.05036-11","article-title":"Nosocomial outbreak of VIM-1-producing Klebsiella pneumoniae of multilocus sequence type 15: molecular basis, clinical risk factors, and outcome","volume":"56","author":"Sanchez-Romero","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/jac\/dkn547","article-title":"Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the eastern USA","volume":"63","author":"Endimiani","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib5","doi-asserted-by":"crossref","first-page":"e22751","DOI":"10.1371\/journal.pone.0022751","article-title":"Prospective genomic characterization of the german enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology","volume":"6","author":"Mellmann","year":"2011","journal-title":"PLoS One"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib6","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1128\/AAC.01595-10","article-title":"Genomic analysis of Acinetobacter baumannii A118 by comparison of optical maps: identification of structures related to its susceptibility phenotype","volume":"55","author":"Ramirez","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib7","doi-asserted-by":"crossref","first-page":"e1800","DOI":"10.1371\/journal.pone.0001800","article-title":"Klebsiella pneumoniae multiresistance plasmid pMET1: similarity with the Yersinia pestis plasmid pCRY and integrative conjugative elements","volume":"3","author":"Soler Bistue","year":"2008","journal-title":"PLoS One"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1128\/AAC.29.2.315","article-title":"Plasmid-encoded amikacin resistance in multiresistant strains of Klebsiella pneumoniae isolated from neonates with meningitis","volume":"29","author":"Woloj","year":"1986","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib9","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1128\/JB.00315-09","article-title":"Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis","volume":"191","author":"Wu","year":"2009","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib10","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1002\/elps.200900074","article-title":"A new single-step quantitative pathogen detection system: template-tagging followed by multiplex asymmetric PCR using common primers and CE-SSCP","volume":"30","author":"Shin","year":"2009","journal-title":"Electrophoresis"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/10665270050081478","article-title":"A greedy algorithm for aligning DNA sequences","volume":"7","author":"Zhang","year":"2000","journal-title":"J Comput Biol"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib12","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1093\/bioinformatics\/bti553","article-title":"Act: the artemis comparison tool","volume":"21","author":"Carver","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib13","series-title":"Performance Standards for Antimicrobial Susceptibility Testing. Approved Standard M100-S15","year":"2005"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1128\/CMR.17.1.14-56.2004","article-title":"Pathogenicity islands in bacterial pathogenesis","volume":"17","author":"Schmidt","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1423-0127-17-60","article-title":"Molecular characterization of the PhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43","volume":"17","author":"Cheng","year":"2010","journal-title":"J Biomed Sci"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tibs.2004.12.003","article-title":"A novel mechanism for connecting bacterial two-component signal-transduction systems","volume":"30","author":"Eguchi","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib17","doi-asserted-by":"crossref","first-page":"e8662","DOI":"10.1371\/journal.pone.0008662","article-title":"Evolution in quantum leaps: multiple combinatorial transfers of HPI and other genetic modules in Enterobacteriaceae","volume":"5","author":"Paauw","year":"2010","journal-title":"PLoS One"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib18","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1128\/JB.01219-07","article-title":"Characterization of integrative and conjugative element ICEKp1-associated genomic heterogeneity in a Klebsiella pneumoniae strain isolated from a primary liver abscess","volume":"190","author":"Lin","year":"2008","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib19","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1128\/IAI.00522-09","article-title":"Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae","volume":"77","author":"Putze","year":"2009","journal-title":"Infect Immun"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib20","doi-asserted-by":"crossref","first-page":"e1000141","DOI":"10.1371\/journal.pgen.1000141","article-title":"Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice","volume":"4","author":"Fouts","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib21","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1099\/jmm.0.46165-0","article-title":"Investigation of the putative virulence gene magA in a worldwide collection of 495 Klebsiella isolates: magA is restricted to the gene cluster of Klebsiella pneumoniae capsule serotype K1","volume":"54","author":"Struve","year":"2005","journal-title":"J Med Microbiol"},{"key":"10.1111\/j.1469-0691.2012.03886.x_bib22","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1093\/jac\/dkr240","article-title":"Increasing prevalence and dissemination of NDM-1 metallo-beta-lactamase in India: data from the smart study (2009)","volume":"66","author":"Lascols","year":"2011","journal-title":"J Antimicrob Chemother"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14645869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14645869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T01:31:17Z","timestamp":1561599077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X14645869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S1198743X14645869"],"URL":"https:\/\/doi.org\/10.1111\/j.1469-0691.2012.03886.x","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}