{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T01:10:47Z","timestamp":1700529047632},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T00:00:00Z","timestamp":1190937600000},"content-version":"vor","delay-in-days":9036,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A total of 250 individuals belonging to 19 different families, identified through established propositi were simultaneously screened for hereditary spherocytosis (SPH), using stringent criteria, and 27 well\u2010known polymorphic genetic marker systems.<\/jats:p><jats:p>The segregation analysis indicated that the pattern of inheritance of SPH in these families, being autosomal and dominant, had a 100 % penetrance. A statistical analysis, using the LIPED computer program of Ott (1974), revealed the absence of close linkage between <jats:italic>SPH<\/jats:italic> and <jats:italic>AB0, ACP1, ADA, AK1, C3, D1A2, ESD, FY, CC, GL01, GM, GPT1, HLA, HPA, JK, K, KM, MNS, P, PGD, PGM1, PGP, PI<\/jats:italic>, and <jats:italic>RH.<\/jats:italic><\/jats:p><jats:p>Since an earlier study by other investigators had convincingly suggested a linkage between <jats:italic>SPH<\/jats:italic> and <jats:italic>GM<\/jats:italic>, we subjected the data to further analysis and found no significant heterogeneity in our recombination values of linkage between <jats:italic>SPH<\/jats:italic> and <jats:italic>GM<\/jats:italic>, or any of the other informative loci.<\/jats:p>","DOI":"10.1111\/j.1469-1809.1983.tb00970.x","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T09:48:28Z","timestamp":1190972908000},"page":"55-65","source":"Crossref","is-referenced-by-count":4,"title":["Absence of close linkage between <i>Hereditary Spherocytosis (SPH)<\/i> and 24 genetic marker systems including <i>HLA<\/i> and <i>GM<\/i>"],"prefix":"10.1111","volume":"47","author":[{"given":"B. 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