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However, whereas the three common T\u2010T, T\u2010C and C\u2010C haplotypes corresponding to the \u025b2, \u025b3 and \u025b4 alleles are well known, the last C\u2010T haplotype (GenBank accession AY077451), encoding a fourth apoE allele, has rarely been reported. We detected this fourth allele in a Caucasian patient with motor neuron disease (MND). According to the literature we refer to this allele as \u025b3r. Although several explanations may be proposed for its formation, the existence of this fourth allele is consistent with the evolutionary hypothesis generally accepted for the apoE alleles. The rarity and physiological role of \u025b3r remains to be explained, and requires further investigation.<\/jats:p>","DOI":"10.1111\/j.1469-1809.2006.00344.x","type":"journal-article","created":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T17:38:51Z","timestamp":1169487531000},"page":"496-500","source":"Crossref","is-referenced-by-count":33,"title":["The Missing ApoE Allele"],"prefix":"10.1111","volume":"71","author":[{"given":"D.","family":"Seripa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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