{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:54:59Z","timestamp":1770267299388,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We previously identified a novel locus for plasma triglyceride (TG) levels on chromosome 1p31\u201332 by genome\u2010wide linkage analysis in the GeneQuest population with familial and premature coronary artery disease (CAD). Here we tested a hypothesis that variants in<jats:italic>LRP8<\/jats:italic>, a gene that is under the 1p31\u201332 linkage peak and associated with risk of familial and premature CAD and increased platelet activation, are associated with TG levels. Seven tagSNPs that cover the entire<jats:italic>LRP8<\/jats:italic>gene were characterized in 358 GeneQuest Caucasian probands. Only SNP R952Q (rs5174) was associated with TG levels (<jats:italic>P<\/jats:italic>\u2010adj = 0.0016), and this finding was replicated in one other independent population of 134 patients with early\u2010onset myocardial infarction (males &lt;45; females &lt;55;<jats:italic>P<\/jats:italic>\u2010adj = 0.0098). TG levels were higher in the group with higher body mass index (BMI \u2265 25) than in the group with lower BMI (BMI &lt; 25). The association was significant in the overweight group (<jats:italic>P<\/jats:italic>\u2010adj = 0.0029) or in the smoking group (<jats:italic>P<\/jats:italic>\u2010adj = 0.0004), but not in the group with normal BMI or without smoking history. These results suggest that genetic variant R952Q of<jats:italic>LRP8<\/jats:italic>is associated with increased plasma TG levels in patients who are overweight and have premature CAD\/MI and history of smoking.<\/jats:p>","DOI":"10.1111\/j.1469-1809.2012.00705.x","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T08:46:03Z","timestamp":1331196363000},"page":"193-199","source":"Crossref","is-referenced-by-count":10,"title":["Genetic Variant R952Q in<i>LRP8<\/i>is Associated with Increased Plasma Triglyceride Levels in Patients with Early\u2010Onset CAD and MI"],"prefix":"10.1111","volume":"76","author":[{"given":"Gong\u2010Qing","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing K.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115130"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.11.1.2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00031-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6973.170"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01127-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2.528"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-008-0079-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.75"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.09.068"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.61"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-007-0006-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1055\/s-0038-1646789","article-title":"Triglyceride lipase activity and human platelets","volume":"41","author":"Lote K.","year":"1979","journal-title":"Thromb Haemost"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.10.3007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136370"},{"key":"e_1_2_6_16_1","first-page":"89","article-title":"The independent relationship between triglycerides and coronary heart disease","volume":"5","author":"Morrison A.","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"e18\u2013e209","DOI":"10.1161\/CIR.0b013e3182009701","article-title":"Heart disease and stroke statistics\u20102011 update: A report from the American Heart Association","volume":"123","author":"Roger V. 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