{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:25:46Z","timestamp":1761863146152},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T00:00:00Z","timestamp":1343001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The association of <jats:italic>FTO<\/jats:italic> gene variants with body mass index (BMI) and other obesity characteristics is well established. However, uncertainties remain whether the association is present only in young populations and whether it is attributable to body fat mass specifically. We aimed to clarify these two questions in a large sample (<jats:italic>N<\/jats:italic>= 4,523 individuals) of middle\u2010aged and older (range 40\u201380 years) British female twins. The women were assessed for BMI, waist and hip circumference, total lean (LBM) and fat (FBM) body mass. Since the majority of <jats:italic>FTO<\/jats:italic> association signals have been reported in a haploblock bordering 52,355\u201352,408 kb (on chromosome 16q12.2), we examined five genotyped and 43 imputed SNPs mapped to this block. Canonical correlation and other association analyses showed significant and consistent association between the selected SNP and studied body composition phenotypes, with <jats:italic>p<\/jats:italic>\u2010values reaching <jats:italic>p<\/jats:italic>= 0.000004. Of particular interest, in addition to the expected significant associations between <jats:italic>FTO<\/jats:italic> variants and FBM, we also identified significant associations with LBM. These results suggest that the association between <jats:italic>FTO<\/jats:italic> variants and body composition phenotypes is present across a wide range of ages, and that <jats:italic>FTO<\/jats:italic> appears primarily to affect the amount of body soft tissue, influencing both fat and lean mass.<\/jats:p>","DOI":"10.1111\/j.1469-1809.2012.00720.x","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T10:05:32Z","timestamp":1343037932000},"page":"333-341","source":"Crossref","is-referenced-by-count":21,"title":["Association of FTO gene variants with body composition in UK twins"],"prefix":"10.1111","volume":"76","author":[{"given":"Gregory","family":"Livshits","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Malkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Moayyeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy D","family":"Spector","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,23]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"An introduction to multivariate statistical analysis","author":"Anderson T. 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