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Until now, there has been no systematic investigation of IK channel localization within different epithelia. IK channel immunoreactivity was present in most epithelia, where it occurred in surface membranes of epithelial cells. It was found in all stratified epithelia, including skin, cornea, oral mucosa, vaginal mucosa, urothelium and the oesophageal lining. It occurred in the ducts of fluid\u2010secreting glands, the salivary glands, lacrimal glands and pancreas, and in the respiratory epithelium. A low level of expression was seen in serous acinar cells. It was also found in other epithelia with fluid\u2010exchange properties, the choroid plexus epithelium, the ependyma, visceral pleura and peritoneum, bile ducts and intestinal lining epithelium. However, there was little or no expression in vascular endothelial cells, kidney tubules or collecting ducts, lung alveoli, or in sebaceous glands. It is concluded that the channel is present in surface epithelia (e.g. skin) where it has a cell\u2010protective role against osmotic challenge, and in epithelia where there is anion secretion that is facilitated by a K<jats:sup>+<\/jats:sup>current\u2010dependent hyperpolarization. It was also in some epithelial cells where its roles are as yet unknown.<\/jats:p>","DOI":"10.1111\/j.1469-7580.2006.00515.x","type":"journal-article","created":{"date-parts":[[2006,1,26]],"date-time":"2006-01-26T17:21:04Z","timestamp":1138296064000},"page":"219-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["The distribution of intermediate\u2010conductance, calcium\u2010activated, potassium (IK) channels in epithelial cells"],"prefix":"10.1111","volume":"208","author":[{"given":"Nichola","family":"Thompson\u2010Vest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutake","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie","family":"Hunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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