{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T18:57:38Z","timestamp":1775588258756,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The semi\u2010dominant<jats:italic>Br<\/jats:italic>mutation affects presphenoid growth, producing the facial retrognathism and globular neurocranial vault that characterize heterozygotes. We analysed the impact of this mutation on skull shape, comparing heterozygotes to wildtype mice, to determine if the effects are skull\u2010wide or confined to the sphenoid region targeted by the mutation. In addition, we examined patterns of variability of shape for the skull as a whole and for three regions (basicranium, face and neurocranium). We found that the<jats:italic>Br<\/jats:italic>mice differed significantly from wildtype mice in skull shape in all three regions as well as in the shape of the skull as a whole. However, the significant increases in variance and fluctuating asymmetry were found only in the basicranium of mutant mice. These results suggest that the mutation has a significant effect on the underlying developmental architecture of the skull, which produces an increase in phenotypic variability that is localized to the anatomical region in which the mean phenotype is most dramatically affected. These results suggest that the same developmental mechanisms that produce the change in phenotypic mean also produce the change in variance.<\/jats:p>","DOI":"10.1111\/j.1469-7580.2006.00527.x","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T18:06:20Z","timestamp":1141841180000},"page":"361-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Canalization and developmental stability in the Brachyrrhine mouse"],"prefix":"10.1111","volume":"208","author":[{"given":"Katherine Elizabeth","family":"Willmore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam Leah","family":"Zelditch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Ah\u2010Seng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Lozanoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Hallgr\u00edmsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/325345a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5347(97)01029-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/1811018a0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1071\/BI9590506","article-title":"Selection for an invariant character, vibrissae number in the house mouse","volume":"12","author":"Dunn RB","year":"1959","journal-title":"Aust J Biol Sci"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/147.3.1155"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.10182"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0021-8782.2004.00356.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2006.05075.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017535930657"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/17.5.403"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2002.tb00117.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-142X.2003.03057.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/jhev.1999.0335"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8644(2000)43:31 <117::AID-AJPA5>3.3.CO;2-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000147492"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1994)031<0417:ACBMIM>2.3.CO;2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900903"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420470409"},{"key":"e_1_2_6_21_1","first-page":"547","article-title":"Morphological deficiency in the prenatal anterior cranial base of midfacially retrognathic mice","volume":"188","author":"Ma W","year":"1996","journal-title":"J Anat"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(1999)12:5<315::AID-CA2>3.0.CO;2-2"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(01)00105-4"},{"key":"e_1_2_6_24_1","volume-title":"Sage3D.","author":"Marquez E","year":"2004"},{"key":"e_1_2_6_25_1","first-page":"297","article-title":"Genetical control of stability in development","volume":"7","author":"Mather K","year":"1953","journal-title":"Nature"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.10034"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/genetics\/120.1.213","article-title":"Diazinon resistance in the Australian sheep blowfly, Lucilia cuprina","volume":"120","author":"McKenzie JA","year":"1988","journal-title":"Genetics"},{"key":"e_1_2_6_28_1","volume-title":"Morphologika","author":"O'Higgins P","year":"1998"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(76)90069-5"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.es.17.110186.002135"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/oso\/9780195143454.003.0017","volume-title":"Developmental Instability (DI): Causes and Consequences","author":"Palmer R","year":"2003"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.1959.tb03033.x"},{"key":"e_1_2_6_33_1","volume-title":"Canalization and Gene Control","author":"Rendel JM","year":"1967"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/24550"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-1878(200012)22:12<1095::AID-BIES7>3.0.CO;2-A"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300003967"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.es.22.110191.000433"},{"key":"e_1_2_6_38_1","volume-title":"Factors of Evolution","author":"Schmalhausen II","year":"1949"},{"key":"e_1_2_6_39_1","first-page":"27","article-title":"New mutants","volume":"35","author":"Searle A","year":"1966","journal-title":"Mouse Letter"},{"key":"e_1_2_6_40_1","volume-title":"Simple3D","author":"Sheets HD","year":"2004"},{"key":"e_1_2_6_41_1","volume-title":"3DStand","author":"Sheets HD","year":"2004"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102303999"},{"key":"e_1_2_6_43_1","volume-title":"Morpheus","author":"Slice DE","year":"1994"},{"key":"e_1_2_6_44_1","volume-title":"Craniofacial Development","author":"Sperber GH","year":"2001"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.19.10215"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2005.05026.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.1962.tb03206.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/150563a0"},{"key":"e_1_2_6_49_1","volume-title":"Strategy of the Genes","author":"Waddington CH","year":"1957"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.1996.tb02339.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1420-9101.2003.00568.x"}],"container-title":["Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1469-7580.2006.00527.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1469-7580.2006.00527.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T07:10:29Z","timestamp":1706944229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1469-7580.2006.00527.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1469-7580.2006.00527.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1469-7580.2006.00527.x","archive":["Portico"],"relation":{},"ISSN":["0021-8782","1469-7580"],"issn-type":[{"value":"0021-8782","type":"print"},{"value":"1469-7580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"2006-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}