{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:37:29Z","timestamp":1792791449490,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T00:00:00Z","timestamp":1277164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Premature closure of the sagittal suture occurs as an isolated (nonsyndromic) birth defect or as a syndromic anomaly in combination with other congenital dysmorphologies. The genetic causes of sagittal nonsyndromic craniosynostosis (NSC) remain unknown. Although variation of the dysmorphic (scaphocephaly) skull shape of sagittal NSC cases has been acknowledged, this variation has not been quantitatively studied three\u2010dimensionally (3D). We have analyzed the computed tomography skull images of 43 infants (aged 0.9\u20139\u2003months) with sagittal NSC using anatomical landmarks and semilandmarks to quantify and characterize the within\u2010sample phenotypic variation. Suture closure patterns were defined by dividing the sagittal suture into three sections (anterior, central, posterior) and coding each section as \u2018closed\u2019 or \u2018fused\u2019. Principal components analysis of the Procrustes shape coordinates representing the skull shape of 43 cases of NSC did not separate individuals by sex, chronological age, or dental stages of the deciduous maxillary first molar. However, analysis of suture closure pattern allowed separation of these data. The central section of the sagittal suture appears to be the first to fuse. Then, at least two different developmental paths towards complete fusion of the sagittal suture exist; either the anterior section or the posterior section is the second to fuse. Results indicate that according to the sequence of sagittal suture closure patterns, different craniofacial complex shapes are observed. The relationship between craniofacial shape and suture closure indicates not only which suture fused prematurely (in our case the sagittal suture), but also the pattern of the suture closure. Whether these patterns indicate differences in etiology cannot be determined with our data and requires analysis of longitudinal data, most appropriately of animal models where prenatal conditions can be monitored.<\/jats:p>","DOI":"10.1111\/j.1469-7580.2010.01258.x","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T06:07:42Z","timestamp":1277186862000},"page":"85-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["New insights into the relationship between suture closure and craniofacial dysmorphology in sagittal nonsyndromic craniosynostosis"],"prefix":"10.1111","volume":"217","author":[{"given":"Yann","family":"Heuz\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeon A.","family":"Boyadjiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex A.","family":"Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah","family":"Cherkez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Boggan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan T.","family":"Richtsmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.54.3.0384"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1965.22.3.0229"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhevol.2008.09.002"},{"key":"e_1_2_7_5_1","volume-title":"Morphometric Tools for Landmark Data: Geometry and Biology","author":"Bookstein FL","year":"1991"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(97)85012-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32208"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2007.00393.x"},{"key":"e_1_2_7_9_1","first-page":"A1795","article-title":"Analysis of candidate genes for non\u2010syndromic craniosynostosis","volume":"71","author":"Boyadjiev SA","year":"2002","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_10_1","first-page":"21","volume-title":"Craniosynostosis: Diagnosis, Evaluation, and Management","author":"Cohen MM","year":"1986"},{"key":"e_1_2_7_11_1","first-page":"112","volume-title":"Craniosynostosis: Diagnosis, Evaluation, and Management","author":"Cohen MM","year":"2000"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1989.70.2.0159"},{"key":"e_1_2_7_13_1","first-page":"211","article-title":"A new system of dental age assessment","volume":"45","author":"Demirjian A","year":"1973","journal-title":"Hum Biol"},{"key":"e_1_2_7_14_1","volume-title":"Statistical shape analysis","author":"Dryden IL","year":"1998"},{"key":"e_1_2_7_15_1","first-page":"293","article-title":"Craniofacial deformation","volume":"6","author":"Graham JM","year":"1998","journal-title":"Balliere\u2019s Clin Paediatr"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02844310600610264"},{"key":"e_1_2_7_17_1","unstructured":"GunzP(2005)Statistical and geometric reconstruction of hominid crania: reconstructing australopithecine ontogeny.Ph.D.thesis University of Vienna Vienna."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-27614-9_3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050348"},{"key":"e_1_2_7_20_1","first-page":"1","article-title":"Cranial Variation in Man. 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