{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:15:15Z","timestamp":1789726515302,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T00:00:00Z","timestamp":1341964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This paper describes tooth development in a basal squamate, <jats:italic>Paroedura picta.<\/jats:italic> Due to its reproductive strategy, mode of development and position within the reptiles, this gecko represents an excellent model organism for the study of reptile development. Here we document the dental pattern and development of non\u2010functional (null generation) and functional generations of teeth during embryonic development. Tooth development is followed from initiation to cytodifferentiation and ankylosis, as the tooth germs develop from bud, through cap to bell stages. The fate of the single generation of non\u2010functional (null generation) teeth is shown to be variable, with some teeth being expelled from the oral cavity, while others are incorporated into the functional bone and teeth, or are absorbed. Fate appears to depend on the initiation site within the oral cavity, with the first null generation teeth forming before formation of the dental lamina. We show evidence for a stratum intermedium layer in the enamel epithelium of functional teeth and show that the bicuspid shape of the teeth is created by asymmetrical deposition of enamel, and not by folding of the inner dental epithelium as observed in mammals.<\/jats:p>","DOI":"10.1111\/j.1469-7580.2012.01531.x","type":"journal-article","created":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T07:31:12Z","timestamp":1341991872000},"page":"195-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Tooth development in a model reptile: functional and null generation teeth in the gecko <i>Paroedura picta<\/i>"],"prefix":"10.1111","volume":"221","author":[{"given":"Oldrich","family":"Zahradnicek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Horacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail S.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/1444828"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00495639"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zool.2007.01.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.03.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00451481"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.10455"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-0950-2"},{"key":"e_1_2_7_9_1","first-page":"117","volume-title":"Biology of the Reptilia","author":"Edmund AG","year":"1969"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1096-3642.2001.tb00629.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.10.020"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21438"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.052415"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.06.034"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-8166(97)80044-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2008.00258.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21275"},{"key":"e_1_2_7_18_1","first-page":"463","article-title":"Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non\u2010dividing cells express growth stimulating Fgf\u20104 gene","volume":"38","author":"Jernvall J","year":"1994","journal-title":"Int J Dev Biol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004270050206"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1186"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1139\/z06-152"},{"key":"e_1_2_7_22_1","first-page":"793","article-title":"\u00dcber die Zahnentwicklung bei Iguana tuberculata","author":"Leche W","year":"1893","journal-title":"Anat Anz"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2307\/1445979"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051650302"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20674"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.10972"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(68)90091-5"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22502"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.002618"},{"key":"e_1_2_7_30_1","first-page":"96","article-title":"Inner enamel epithelia synthesize and secrete enamel proteins during mouse molar occlusal \u2018enamel\u2010free area\u2019 development","volume":"11","author":"Nakamura M","year":"1991","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21828"},{"key":"e_1_2_7_32_1","first-page":"1377","article-title":"[A histological study of the gekko tooth (author\u2019s translation)]","volume":"64","author":"Ogawa T","year":"1977","journal-title":"Shigaku"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907236107"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1971.0097"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(74)90012-5"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345980770090901"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(78)90145-0"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091310207"},{"key":"e_1_2_7_39_1","volume-title":"Comparative Odontology","author":"Peyer B","year":"1986"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002784107"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00995429"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20721"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08838"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.10563"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008200290001203"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356308993957"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10220"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2010.00772.x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1139\/z87-438"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1996.tb00204.x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(89)90043-5"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2001.tb00744.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07178"},{"key":"e_1_2_7_54_1","first-page":"148","article-title":"Early dentition development in the lower jaws of Anguis fragilis and Lacertu agilis","volume":"64","author":"Westergaard B","year":"1988","journal-title":"Memo SOC Fauna Flora Fenn"},{"key":"e_1_2_7_55_1","first-page":"55","article-title":"The pattern of embryonic tooth initiation in reptiles. Teeth revised","volume":"53","author":"Westergaard B","year":"1988","journal-title":"Mem Mus Nat Hist Paris Ser C"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7998.1986.tb03657.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001870407"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syq048"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2010.02.006"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2008.06.008"}],"container-title":["Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1469-7580.2012.01531.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1469-7580.2012.01531.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T01:23:20Z","timestamp":1698629000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1469-7580.2012.01531.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,11]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1469-7580.2012.01531.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1469-7580.2012.01531.x","archive":["Portico"],"relation":{},"ISSN":["0021-8782","1469-7580"],"issn-type":[{"value":"0021-8782","type":"print"},{"value":"1469-7580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,11]]},"assertion":[{"value":"2012-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}