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We introduce a novel technique to easily and efficiently quantify individual cranial bone volume and relative bone mineral density across the murine skull from high resolution computed tomography images. The approach can be combined with existing quantitative morphometric methods to provide details of bone growth and bone quality, which can be used to make inferences about regulatory effects local to individual bones and identify locations and developmental times for which additional analyses are warranted. Analysis of the <jats:italic>Fgfr2<\/jats:italic><jats:sup>+\/Y394C<\/jats:sup> mouse model of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>eare\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tevenson cutis gyrata syndrome, an <jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>\u2010related craniosynostosis syndrome, is used to demonstrate the method. Mutants and unaffected littermates display similar bone volume and relative bone density at birth, followed by significant differences at postnatal day eight. The change in rates of bone volume growth occurs similarly for all bones of the skull, regardless of origin, location or association with craniosynostosis. These results suggest an association between low bone density, low bone volume, and <jats:styled-content style=\"fixed-case\"><jats:italic>Fgfr<\/jats:italic><\/jats:styled-content> craniosynostosis mutations. Our novel technique provides an initial quantitative evaluation of local shifts in bone maturation across the skull of animal models.<\/jats:p>","DOI":"10.1111\/j.1469-7580.2012.01555.x","type":"journal-article","created":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T04:01:36Z","timestamp":1344830496000},"page":"434-442","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of a <scp>B<\/scp>eare\u2010<scp>S<\/scp>tevenson syndrome <scp><i>Fgfr2<\/i> Y<\/scp>394<scp>C<\/scp> mutation on early craniofacial bone volume and relative bone mineral density in mice"],"prefix":"10.1111","volume":"221","author":[{"given":"Christopher J.","family":"Percival","sequence":"first","affiliation":[{"name":"Department of Anthropology Penn State University University Park PA 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