{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:28:30Z","timestamp":1761323310002},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T00:00:00Z","timestamp":1096502400000},"content-version":"vor","delay-in-days":2556,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>We iontophoretically applied <jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>\u2010nitro\u2010L\u2010arginine (<jats:sc>l<\/jats:sc>\u2010NOArg), an inhibitor of nitric oxide synthase (NOS), to cells (<jats:styled-content><jats:italic>n<\/jats:italic>= 77<\/jats:styled-content>) in area 17 of anaesthetized and paralysed cats while recording single\u2010unit activity extracellularly. In twenty\u2010nine out of seventy\u2010seven cells (38%), compounds altering NO levels affected visual responses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In twenty\u2010five out of twenty\u2010nine cells, <jats:sc>l<\/jats:sc>\u2010NOArg non\u2010selectively reduced visually elicited responses and spontaneous activity. These effects were reversed by co\u2010application of <jats:sc>l<\/jats:sc>\u2010arginine (<jats:sc>l<\/jats:sc>\u2010Arg), which was without effect when applied alone. Application of the NO donor diethylamine\u2010nitric oxide (DEA\u2010NO) produced excitation in three out of eleven cells, all three cells showing suppression by <jats:sc>l<\/jats:sc>\u2010NOArg. In ten cells the effect of the soluble analogue of cGMP, 8\u2010bromo\u2010cGMP, was tested. In three of those in which <jats:sc>l<\/jats:sc>\u2010NOArg application reduced firing, 8\u2010bromo\u2010cGMP had an excitatory effect. In six out of fifteen cells tested, L\u2010NOArg non\u2010selectively reduced responses to NMDA and \u03b1\u2010amino\u20103\u2010hydroxy\u20105\u2010methylisoxasole\u20104\u2010propionic acid (AMPA). Again, co\u2010application of <jats:sc>l<\/jats:sc>\u2010Arg reversed this effect, without enhancing activity beyond control values.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In a further subpopulation of ten cells, <jats:sc>l<\/jats:sc>\u2010NOArg decreased responses to ACh in five.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In four out of twenty\u2010nine cells <jats:sc>l<\/jats:sc>\u2010NOArg produced the opposite effect and increased visual responses. This was reversed by co\u2010application of <jats:sc>l<\/jats:sc>\u2010Arg. Some cells were also affected by 8\u2010bromo\u2010cGMP and DEA\u2010NO in ways opposite to those described above. It is possible that the variety of effects seen here could also reflect trans\u2010synaptic activation, or changes in local circuit activity. However, the most parsimonious explanation for our data is that NO differentially affects the activity of two populations of cortical cells, in the main causing a non\u2010specific excitation.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/j.1469-7793.1997.467be.x","type":"journal-article","created":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T07:39:25Z","timestamp":1096529965000},"page":"467-478","source":"Crossref","is-referenced-by-count":28,"title":["Actions of compounds manipulating the nitric Oxide system in the cat primary visual cortex"],"prefix":"10.1113","volume":"504","author":[{"given":"Javier","family":"Cudeiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casto","family":"Rivadulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Rosa Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth L.","family":"Grieve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Mart\u00ednez\u2010Conde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Acu\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,30]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903040412"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903340307"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903480402"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/347768a0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.22.9030"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-11-04007.1988"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90043-4"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1152\/jn.1994.71.1.146","article-title":"Modulatory influence of putative inhibitors of nitric oxide synthesis on visual processing in the cat lateral geniculate nucleus","volume":"71","author":"Cudeiro J.","year":"1994","journal-title":"Journal of Neurophysiology"},{"key":"e_1_2_5_9_1","first-page":"650.2","article-title":"Application of l\u2010Arg and l\u2010NOArg modify cellular responses in the primary visual cortex of the cat","volume":"21","author":"Cudeiro J.","year":"1995","journal-title":"Society for Neuroscience Abstracts"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01175.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021159"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.17.7797"},{"key":"e_1_2_5_13_1","first-page":"606","article-title":"Local cortical lesions abolish lateral inhibition at direction selective cells in cat visual cortex","volume":"681","author":"Eysel U. 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