{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:38:48Z","timestamp":1773657528382,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T00:00:00Z","timestamp":1096502400000},"content-version":"vor","delay-in-days":2495,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Although the first evidence of a relationship between the thyroid and metabolism was reported in 1895, the mechanism by which thyroid hormones influence resting metabolic rate in whole animals is still poorly understood. This paper reports an attempt to test whether diiodothyronines (T<jats:sub>2<\/jats:sub>s) and triiodothyronine (T<jats:sub>3<\/jats:sub>) have different roles in the control of resting metabolism (RM).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Changes in resting metabolic rate were measured in hypothyroid rats treated acutely (25\u03bcg (100 g body weight)<jats:sup>\u22121<\/jats:sup>) either with one of the T<jats:sub>2<\/jats:sub>s or with T<jats:sub>3<\/jats:sub>. Injection of T<jats:sub>3<\/jats:sub> induced an increase of about 35% in RM that started 25\u201330 h after the injection and lasted until 5\u20136 days after the injection, the maximal value being observed at 50\u201375 h. The injection of T<jats:sub>2<\/jats:sub>s evoked a temporally different pattern of response. The increases in RM started 6\u201312 h after the injection, had almost disappeared after 48 h, and the maximal stimulation was observed at 28\u201330 h.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>When actinomycin D (an inhibitor of protein synthesis) and T<jats:sub>3<\/jats:sub> were given together, the stimulation of RM was almost completely abolished. The simultaneous injection of actinomycin D and either of the T<jats:sub>2<\/jats:sub>s, on the other hand, did not cause any attenuation of the stimulation seen with the T<jats:sub>2<\/jats:sub>s alone.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Following chronic treatment (3 weeks) with either T<jats:sub>3<\/jats:sub> or T<jats:sub>2<\/jats:sub>s there was a stimulation of organ growth only after the administration of T<jats:sub>3<\/jats:sub>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Chronic administration of either T<jats:sub>2<\/jats:sub>s or T<jats:sub>3<\/jats:sub> to hypothyroid rats significantly enhanced the oxidative capacity of each of the tissues considered. In the case of T<jats:sub>2<\/jats:sub>s the stimulation was almost the same whether it was expressed as an increase in specific activity or total tissue activity. In the case of T<jats:sub>3<\/jats:sub> the increases were, in the main, secondary to the hypertrophic or hyper plastic effect.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results indicate that T<jats:sub>2<\/jats:sub>s and T<jats:sub>3<\/jats:sub> exert different effects on RM. The effects of T<jats:sub>2<\/jats:sub>s are rapid and possibly mediated by their direct interaction with mitochondria. Those of T<jats:sub>3<\/jats:sub> are slower and more prolonged, and at least partly attributable to a modulation of the cellularity of tissues that are metabolically very active.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/j.1469-7793.1997.529bb.x","type":"journal-article","created":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T07:17:30Z","timestamp":1096528650000},"page":"529-538","source":"Crossref","is-referenced-by-count":96,"title":["How the thyroid controls metabolism in the rat: different roles for triiodothyronine and diiodothyronines"],"prefix":"10.1113","volume":"505","author":[{"given":"Maria","family":"Moreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Lanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assunta","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Goglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,30]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-1-84"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(79)90066-5"},{"key":"e_1_2_5_3_1","first-page":"519","article-title":"Increased oxidative capacity in skeletal muscle from cold\u2010acclimated ducklings: a comparison with rats","volume":"88","author":"Barr\u00e8 H.","year":"1987","journal-title":"Comparative Biochemistry and Physiology"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1987.253.3.E255"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0620315"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3170913"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.4.1682"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1290035"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0130275"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.136.3513.315"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(72)90094-2"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1016\/S0021-9258(17)43215-7","article-title":"Rapid effect of triiodothyronine on hepatic gene expression. 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