{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:49:18Z","timestamp":1791906558710,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,9,22]],"date-time":"2004-09-22T00:00:00Z","timestamp":1095811200000},"content-version":"vor","delay-in-days":2183,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Extracellular recording techniques have been used to study nerve impulses in single sensory nerve terminals in guinea\u2010pig cornea isolated <jats:italic>in vitro.<\/jats:italic><\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Nerve impulses occurred spontaneously and were evoked by electrical stimulation of the ciliary nerves.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The nerve impulses were identified as originating in polymodal receptors, mechano\u2010receptors or \u2018cold\u2019 receptors. All three types are believed to be nociceptors.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Tetrodotoxin (TTX, 1 \u03bc<jats:sc>m<\/jats:sc>) blocked nerve impulses evoked by electrical stimulation of the ciliary nerves. However, ongoing and\/or naturally evoked nerve impulses persisted in the presence of TTX in all three types of receptors. Lignocaine (lidocaine; 1 m<jats:sc>m<\/jats:sc>) blocked all electrical activity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>TTX\u2010resistant sodium channels therefore play a major role in generating the action potentials that signal pain to the brain.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/j.1469-7793.1998.211bf.x","type":"journal-article","created":{"date-parts":[[2004,9,22]],"date-time":"2004-09-22T07:56:18Z","timestamp":1095839778000},"page":"211-217","source":"Crossref","is-referenced-by-count":185,"title":["Tetrodotoxin\u2010resistant impulses in single nociceptor nerve terminals in guinea\u2010pig cornea"],"prefix":"10.1113","volume":"512","author":[{"given":"James A.","family":"Brock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth 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