{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:49:08Z","timestamp":1760255348253},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,9,22]],"date-time":"2004-09-22T00:00:00Z","timestamp":1095811200000},"content-version":"vor","delay-in-days":2152,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The acute effects of neurotrophic factors on the frequency of spontaneous transmitter release (miniature endplate potentials (MEPPs)) from motor nerve terminals has been examined in skeletal muscles of neonatal mice aged between 9 and 20 days. The following factors were tested at a concentration of 50 ng ml<jats:sup>\u22121<\/jats:sup>: brain\u2010derived neurotrophic factor (BDNF), neurotrophin\u20103 (NT\u20103), neurotrophin\u20104 (NT\u20104), ciliary neuronotrophic factor (CNTF), leukaemia inhibitory factor (LIF), insulin\u2010like growth factors 1 and 2 (IGF\u20101 and IGF\u20102), and glial cell line\u2010derived neurotrophic factor (GDNF). In some experiments, the responses to 2 \u03bc<jats:sc>m<\/jats:sc> LaCl<jats:sub>3<\/jats:sub> and 10 m<jats:sc>m<\/jats:sc> K<jats:sup>+<\/jats:sup>, or to 2\u20135 n<jats:sc>m<\/jats:sc> purified \u03b1\u2010latrotoxin (\u03b1\u2010LTX) were also measured.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Neither BDNF, NT\u20103, NT\u20104, LIF, IGF\u20101 or IGF\u20102 \u2010 singly or in combination \u2010 caused any significant change in MEPP frequency. GDNF, however, produced a highly significant, 2\u2010fold increase in neurotransmitter release that was reproduced in fourteen muscles.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Potentiation of MEPP frequency in GDNF was of the same order as that induced by tetanic stimulation or substitution of the bathing medium with hypertonic saline; but substantially less than that induced either by lanthanum ions or \u03b1\u2010latrotoxin.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The data suggest that concentrations of GDNF that produce maximal enhancement of motoneurone survival <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> also produce acute, non\u2010saturating enhancement in transmitter release at immature mammalian neuromuscular synapses. Taken together with other reports, these findings suggest that GDNF may mediate both functional and structural plasticity of neonatal neuromuscular junctions.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/j.1469-7793.1998.635bd.x","type":"journal-article","created":{"date-parts":[[2004,9,22]],"date-time":"2004-09-22T07:56:18Z","timestamp":1095839778000},"page":"635-641","source":"Crossref","is-referenced-by-count":33,"title":["Enhancement of spontaneous transmitter release at neonatal mouse neuromuscular junctions by the glial cell line\u2010derived neurotrophic factor (GDNF)"],"prefix":"10.1113","volume":"512","author":[{"given":"Richard R.","family":"Ribchester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis J.","family":"Haddow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri A.","family":"Ushkaryov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,22]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1523\/JNEUROSCI.18-04-01440.1998","article-title":"Synergistic effects of Schwann\u2010 and muscle\u2010derived factors on motoneuron survival involve GDNF and cardiotrophin\u20101 (CT\u20101)","volume":"18","author":"Arce V.","year":"1998","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.124.5.843"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017200"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1523\/JNEUROSCI.17-03-00904.1997","article-title":"Kinetics, Ca2+ dependence, and biophysical properties of integrin\u2010mediated mechanical modulation of transmitter release from frog motor nerve terminals","volume":"17","author":"Chen B. 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