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It is currently unknown to what extent plant fumigation triggers specific transcriptional responses.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>To address this question, and to test the hypothesis that sulfite oxidase (<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content>) is acting in <jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub> detoxification, we compared Arabidopsis wildtype (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content> knockout lines (<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>) facing the impact of 600\u00a0nl\u00a0l<jats:sup>\u22121<\/jats:sup> SO<jats:sub>2<\/jats:sub>, using <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>seq to quantify absolute transcript abundances. These transcriptome data were correlated to sulfur metabolism\u2010related enzyme activities and metabolites obtained from identical samples in a previous study.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p><jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> plants exhibited remarkable and broad regulative responses at the m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> level, especially in transcripts related to sulfur metabolism enzymes, but also in those related to stress response and senescence. Focusing on <jats:italic><jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><\/jats:italic> regulation, no alterations were detectable in the <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>, whereas in <jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> plants we found up\u2010regulation of two splice variants of the <jats:italic>SO<\/jats:italic> gene, although this gene is not functional in this line.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Our data provide evidence for the highly specific coregulation between <jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content> and sulfur\u2010related enzymes like <jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content> reductase, and suggest two novel candidates for involvement in <jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub> detoxification: an apoplastic peroxidase, and defensins as putative cysteine mass storages.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/j.1469-8137.2012.04331.x","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T16:40:34Z","timestamp":1349109634000},"page":"1074-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Impact of <scp>SO<\/scp><sub>2<\/sub> on <i>Arabidopsis thaliana<\/i> transcriptome in wildtype and sulfite oxidase knockout plants analyzed by <scp>RNA<\/scp> deep sequencing"],"prefix":"10.1111","volume":"196","author":[{"given":"Domenica","family":"Hamisch","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Pflanzenbiologie Technische Universit\u00e4t Braunschweig Humboldtstra\u00dfe 1 D\u201038106 Braunschweig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f6rte","family":"Randewig","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Forstbotanik und Baumphysiologie Professur f\u00fcr Baumphysiologie Albert\u2010Ludwigs\u2010Universit\u00e4t Freiburg Georges\u2010K\u00f6hler Allee 53\/54 D\u201079085 Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Schliesky","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie der Pflanzen Heinrich\u2010Heine\u2010Universit\u00e4t Universit\u00e4tsstra\u00dfe 1 D\u201040225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Br\u00e4utigam","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie der Pflanzen Heinrich\u2010Heine\u2010Universit\u00e4t Universit\u00e4tsstra\u00dfe 1 D\u201040225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas P. 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