{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:59:19Z","timestamp":1787014759477,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T00:00:00Z","timestamp":1226448000000},"content-version":"vor","delay-in-days":10087,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>This study suggests that social class has an effect on the incidence of anencephalus and spina bifida, the malformations being more frequent in the lower socio\u2010economic groups. A family study of 226 patients with a CNS malformation suggests that social class also may be important in d\u00e9t\u00e9rmining the recurrence risk of such malformations: there are higher risks in social classes III, IV and V than in social classes I and II.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>R\u00c9SUM\u00c9<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Influence de la classe sociale sur le risque de survenue de l'anenc\u00e9phalie el du spina bifida<\/jats:italic>\n                      Cette \u00e9tude sugg\u00e8re que la classe sociale a un effet sur l'incidence de l'anenc\u00e9phalie et du spina bifida, les malformations \u00e9tant plus fr\u00e9quentes dans les groupes socio\u2010\u00e9conomiques inf\u00e9rieurs. Une \u00e9tude familiale de 226 malades pr\u00e9sentant une malformation du SNC sugg\u00e8re que la classe sociale aussi peut etre importante en d\u00e9terminant le risque de r\u00e9currence de telles malformations: il y a des risques plus \u00e9lev\u00e9s dans les classes sociales III, IV et V que dans les classes sociales I et II.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ZUSAMMENFASSUNG<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Der Einflu\u00df der sozialen Klasse auf das Wiederholungsrisiko bei Anencephalus und<\/jats:italic>\n                      <jats:italic>Spina bifida<\/jats:italic>\n                      Die Autoren dieser Arbeit sind der Ansicht, da\u00df die soziale Klasse einen Einflu\u00df auf die H\u00e4ufigkeit des Anencephalus und der Spina bifida hat. Eine Familienstudie von 226 Patienten mit ZNS\u2010Mi\u00dfbildungen weist darauf hin, da\u00df die soziale Klasse auch f\u00fcr die Bestimmung des Wiederholungsrisikos solcher Mi\u00dfbildungen von Bedeutung sein kann: In den sozialen Klassen III, IV und V ist das Risiko gr\u00f6\u00dfer als in den Klassen I und II.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESUMEN<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Influencia de la close social sobre el riesgo de recurrencia de anencefalia y espina bifida<\/jats:italic>\n                      Este estudio sugiere que la classe social tiene un efecto sobre la incidencia de la anencefalia y la espina bifida, siendo estas malformaciones m\u00e1s frecuentes en los grupos socio\u2010econ\u00f3micos m\u00e1s bajos. Un estudio familiar de 226 pacientes con malformati\u00f3n del SNC sugiere que la clase social tambien puede ser importante en d\u00e9t\u00e9rminar el riesgo de recurrencia de tales malformaciones: existe un riesgo m\u00e1s alto en las clases sociales III, IV y V que en las clases sociales I y II.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1469-8749.1981.tb02437.x","type":"journal-article","created":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T08:24:11Z","timestamp":1279182251000},"page":"155-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Influence of Social Class on the Risk of Recurrence of Anencephalus and Spina Bifida"],"prefix":"10.1111","volume":"23","author":[{"given":"N. C.","family":"Nevin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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Incidence, local variation and geographical factors","volume":"22","author":"Laurence K. M.","year":"1968","journal-title":"British Journal of Preventive and Social Medicine"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196711232772104"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1979.tb01697.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.17.3.203"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.17.2.87"},{"key":"e_1_2_1_15_1","volume-title":"Classification of Occupations","author":"Registrar General","year":"1966"},{"key":"e_1_2_1_16_1","first-page":"67","article-title":"Hypothesis: Anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers","volume":"26","author":"Renwick J. 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