{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:03:53Z","timestamp":1759057433247},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T00:00:00Z","timestamp":1226448000000},"content-version":"vor","delay-in-days":10087,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><jats:p>Two children are described in whom congenital primary hypothyroidism was associated with excessive growth during early childhood and who had typical morphological features of cerebral gigantism. One child was completely athyreotic. This association has been described previously in only one other child.<\/jats:p><\/jats:sec><jats:sec><jats:title>R\u00c9SUM\u00c9<\/jats:title><jats:p> <jats:italic>Gigantisme c\u00e9r\u00e9bral el hypothyroidie cong\u00e9nitale chez deux enfants<\/jats:italic> <\/jats:p><jats:p>L'auteur d\u00e9crit le cas de deux enfants chez qui une hypothyroidie cong\u00e9nitale s\u00e9v\u00e8re \u00e9tait associ\u00e9e \u00e0 une croissance excessive durant la premi\u00e8re enfance avec les caract\u00e9ristiques morphologiques typiques d'un gigantisme d'origine c\u00e9r\u00e9brale. L'un des enfants \u00e9tait compl\u00e8tement athyroidien. Cette association n'avait \u00e9t\u00e9 d\u00e9crite ant\u00e9rieurement que chez un autres enfant.<\/jats:p><\/jats:sec><jats:sec><jats:title>ZUSAMMENFASSUNG<\/jats:title><jats:p>Cerebraler Gigantismus und congenitale Hypothreose bei zwei Kindern<\/jats:p><jats:p>Es werden zwei Kinder beschrieben. bei denen die congenitale Hypothyreose mit einem excessiven Wachstum im fr\u00fchen Kindesalter einherging, sowie mit den typischen morphologischcn Merkmalen des cerebralen Gigantismus. Ein Kind war v\u00f6llig athyreot. Dieser Symptomenkomplex ist bisher erst bei einem Kind beschrieben worden.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESUMEN<\/jats:title><jats:p>Gigantismo cerebral el hipotiroidismo cong\u00e9nito en dos ni\u00f1os<\/jats:p><jats:p>Se describen dos ni\u00f1os en los cuales un hipotiroidismo eong\u00e9nito estaba asociado con un crecimiento excesivo durante la primera infancia y con las caracteristicas morfol\u00f3gicas t\u00edpicas del gigantismo cerebral. Un ni\u00f1o era completamente attire\u00f3tico. Esta asociaci\u00f3n se ha descrito con anterioridad solamente en otro ni\u00f1o.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1469-8749.1981.tb02448.x","type":"journal-article","created":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T10:29:07Z","timestamp":1279189747000},"page":"242-246","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Two Children with Cerebral Gigantism and Congenital Primary Hypothyroidism"],"prefix":"10.1111","volume":"23","author":[{"given":"J. A.","family":"Hulse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,11,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.234.203"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6096.1192"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.55.1.40"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6215.675"},{"key":"e_1_2_1_6_1","first-page":"625","article-title":"Cerebral gigantism","volume":"131","author":"Sotos J. F.","year":"1977","journal-title":"American Journal of Disease of Children"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320020211"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1469-8749.1981.tb02448.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1469-8749.1981.tb02448.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T19:51:19Z","timestamp":1699127479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1469-8749.1981.tb02448.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,4]]}},"alternative-id":["10.1111\/j.1469-8749.1981.tb02448.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1469-8749.1981.tb02448.x","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,4]]},"assertion":[{"value":"2008-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}