{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:09:13Z","timestamp":1792062553286,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T00:00:00Z","timestamp":1182384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>There is much evidence in the literature suggesting that children with congenital blindness can also present autistic like features. The aetiopathogenetic and clinical significance of this association is still unclear. Given the central role played by vision in development, we set out to establish the significance of autistic\u2010like behaviours in children with early\u2010onset severe visual impairment. Our sample comprised 24 children (13 males, 11 females; mean age 5y 2mo; range 2\u201011y) affected by Leber's congenital amaurosis (LCA). The results of our administration of a modified Childhood Austism Rating Scale \u2010 excluding item VII (Visual Responsiveness) \u2010 showed that only four of the children gave an overall score indicating the presence of autism (moreover, of mild\/moderate degree). Hardly any of the children in our LCA sample presented major dysfunctions in their relationships with other people or in their social and emotional responsiveness, thus allowing us to exclude a genuine comorbidity with a picture of autism. Indeed, the risk facing the visually impaired child seems to concern their early interactive experiences, which may be affected by their inability to connect with others, and may be prevented through the development of specific strategies of intervention.<\/jats:p>","DOI":"10.1111\/j.1469-8749.2007.00503.x","type":"journal-article","created":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T07:39:24Z","timestamp":1245742764000},"page":"503-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Leber's congenital amaurosis: is there an autistic component?"],"prefix":"10.1111","volume":"49","author":[{"given":"E","family":"Fazzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Signorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P E","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Lanzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,21]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Autism and Blindness: Research and Reflections","author":"Pring L.","year":"2005"},{"key":"e_1_2_1_3_2","volume-title":"Psychiatric Disorders of Children with Congenital Rubella","author":"Chess S","year":"1971"},{"key":"e_1_2_1_4_2","volume-title":"Retrolental Fibroplasia and Autistic Symptomatology","author":"Chase JB.","year":"1972"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1989.tb04045.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2002.1201"},{"key":"e_1_2_1_7_2","volume-title":"Insights from the Blind","author":"Fraiberg S.","year":"1977"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1037\/0033-295X.97.1.114","article-title":"On acquiring knowledge about people and the capacity to pretend: response to Leslie (1987)","volume":"97","author":"Hobson RP.","year":"1990","journal-title":"Psychol Rev"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30301"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1999.2906"},{"key":"e_1_2_1_11_2","first-page":"41","article-title":"Leber's congenital amaurosis","volume":"241","author":"De Laey JJ.","year":"1991","journal-title":"Bull Soc Belge Ophtalmol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3798(02)00135-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20010"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-973785"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh287"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1997.tb01696.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.2001.00366.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.1978.tb00088.x"},{"key":"e_1_2_1_19_2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_1_20_2","volume-title":"International Classification of Diseases, 10th revision","author":"World Health Organization","year":"1992"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.1992.tb00355.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(99)00059-5"},{"key":"e_1_2_1_23_2","volume-title":"The Childhood Autism Rating Scale (CARS)","author":"Schopler E","year":"1988"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024410702242"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025918616111"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1995.tb01669.x"}],"container-title":["Developmental Medicine &amp; 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