{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:18:27Z","timestamp":1791209907537,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T00:00:00Z","timestamp":1218672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>Institutional deprivation is multifaceted and includes adverse psychosocial and nutrition\u2010related components. In this study we partitioned these risks in relation to cognitive impairment and mental ill health, and explored the mediating role of reduced head\/brain size. There were 138 participants (61 males, 77 females) in the study. Participants were Romanian adoptees who had experienced at least 2 weeks of early institutional deprivation. The sample was stratified on the basis of duration of deprivation (high risk &gt;6mo in institutions) and sub\u2010nutrition (i.e. 1.5 SD below UK age\u2010related norms for weight at UK entry). UK children adopted before 6 months of age and a group of non\u2010institutionally deprived Romanian children constituted the comparison groups. Duration of deprivation was associated with smaller head circumference, lowered IQ, and increased mental heath problems, independently of effects found for sub\u2010nutrition on head circumference and IQ. The mediating role of head circumference was limited to either sub\u2010nourished (IQ) or non\u2010sub\u2010nourished (inattention\/overactivity and disinhibited attachment) subgroups. Many negative effects of early deprivation, including stunted brain growth, occur without sub\u2010nutrition: psychosocial deprivation plays a major role in neurodevelopmental effects of deprivation. Further studies of functional and structural neuroanatomy following institutional deprivation are required to delineate the role of brain development in its effects.<\/jats:p>","DOI":"10.1111\/j.1469-8749.2008.03065.x","type":"journal-article","created":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T07:32:47Z","timestamp":1245742367000},"page":"664-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Is sub\u2010nutrition necessary for a poor outcome following early institutional deprivation?"],"prefix":"10.1111","volume":"50","author":[{"given":"Edmund J S","family":"Sonuga\u2010Barke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Beckett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Kreppner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Castle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Colvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2006.00898.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1037\/0012-1649.43.4.931","article-title":"What predicts normality and impairment following profound early institutional deprivation? A longitudinal examination through childhood","volume":"43","author":"Kreppner J","year":"2007","journal-title":"Dev Psychol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.179.2.97"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.40.1.81"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00343"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0080391"},{"issue":"1","key":"e_1_2_6_8_2","first-page":"45","article-title":"Is complete catch\u2010up possible for stunted malnourished children?","volume":"48","author":"Golden MH","year":"1994","journal-title":"Europ J Clin Nutrition"},{"issue":"1","key":"e_1_2_6_9_2","first-page":"45","article-title":"Reversibility of stunting: epidemiological findings in children from developing countries","volume":"48","author":"Martorell L","year":"1994","journal-title":"Europ J Clin Nutrition"},{"key":"e_1_2_6_10_2","first-page":"203","article-title":"Late \u2018catch\u2010up\u2019 growth after severe infantile subnutrition","volume":"131","author":"Graham GC","year":"1972","journal-title":"Hopkins Med J"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1982.tb13647.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.6.593"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000245360.13949.91"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.11.2005"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0149-7634(03)00007-1","article-title":"The neurobiological consequences of early stress and childhood maltreatment","volume":"27","author":"Teicher MH","year":"2003","journal-title":"Neurosci Behav Physiol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200504000-00006"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.10.008"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(95)00216-2"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/35044558"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198103"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/30.10.1734"},{"key":"e_1_2_6_22_2","volume-title":"Growth Programme (Version 1 & 2)","author":"Boyce L","year":"1993"},{"issue":"1","key":"e_1_2_6_23_2","first-page":"S5","article-title":"Between\u2010population variation in pre\u2010adolescent growth","volume":"48","author":"Ulijaszek SJ","year":"1994","journal-title":"Eur J Clin Nutrition"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(99)00258-5"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36735"},{"key":"e_1_2_6_26_2","volume-title":"Manual for the Wechsler Intelligence Scale for Children. 3rd ed","author":"Wechsler D","year":"1991"},{"key":"e_1_2_6_27_2","volume-title":"Assessment of children\u2019s intelligence and special abilities","author":"Sattler J","year":"1982"},{"key":"e_1_2_6_28_2","volume-title":"British Picture Vocabulary Scale","author":"Dunn LIM","year":"1982"},{"key":"e_1_2_6_29_2","volume-title":"The Coloured Progressive Matrices Test","author":"Raven JC","year":"1965"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012229209190"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/1467-8624.00151"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00472"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2006.01688.x"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2007.01792.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.175.5.444"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-007-9185-5"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.6.1173"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.11.2.142"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2003.11.022"},{"key":"e_1_2_6_40_2","volume-title":"Subnutrition environment and behaviour: new perspectives","author":"Levitsky DA","year":"1979"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1469-8749.2008.03065.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1469-8749.2008.03065.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T18:58:48Z","timestamp":1697050728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1469-8749.2008.03065.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,14]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1111\/j.1469-8749.2008.03065.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1469-8749.2008.03065.x","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,14]]},"assertion":[{"value":"2008-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}