{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:23:34Z","timestamp":1780403014848,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T00:00:00Z","timestamp":1245628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p><jats:bold>Aim\u2002<\/jats:bold> To study the sex ratio (proportion of males) in siblings of individuals diagnosed with autism spectrum disorders (ASDs) as children.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> In the current study, we extended previous studies dealing with the androgen theory of autism and examined sex ratios in the siblings of 326 individuals with ASD (245 males, 81 females) who had been consecutively assessed at two Danish university clinics of child psychiatry during the 25\u2010year period from 1960 to 1985.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Among the 513 siblings, 300 were males and 213 females. This yields a sex ratio of 0.585, which is significantly higher than the Danish live\u2010birth sex ratio over the same period (0.514, <jats:italic>p<\/jats:italic>=0.001). The sibling sex ratio was not associated with the IQ in the autistic probands.<\/jats:p><jats:p><jats:bold>Interpretation\u2002<\/jats:bold> Our findings suggest a potential indirect confirmation of the androgen theory of autism.<\/jats:p>","DOI":"10.1111\/j.1469-8749.2009.03368.x","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T17:27:35Z","timestamp":1245691655000},"page":"289-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sibling sex ratio of individuals diagnosed with autism spectrum disorder as children"],"prefix":"10.1111","volume":"52","author":[{"given":"SVEND ERIK","family":"MOURIDSEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BENTE","family":"RICH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TORBEN","family":"ISAGER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,4]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"The ICD\u201010 Classification of Mental And Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines","author":"World Health Organization","year":"1992"},{"key":"e_1_2_6_3_2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69041-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-004-2003-9"},{"issue":"10","key":"e_1_2_6_6_2","first-page":"3","article-title":"Epidemiology of autistic disorder and other pervasive developmental disorders","volume":"66","author":"Fombonne E","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00194"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(02)01904-6"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115455"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2004.00349.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2005.08.010"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738060210101601"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0446"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-4-970"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1362361305057881"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.02001.x"},{"key":"e_1_2_6_17_2","volume-title":"Mental Disorders: Glossary and Guide to their Classification in Accordance with the Ninth Revision of the International Classification of Diseases","author":"World Health Organization","year":"1978"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01046227"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)65253-1"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem274"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00634"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200001000-00006"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1348\/000712608X369459"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1348\/000712608X311731"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2001.tb00181.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2003.12.002"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2007.02.001"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2006.tb01278.x"}],"container-title":["Developmental Medicine &amp; 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