{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:08:50Z","timestamp":1786486130323,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T00:00:00Z","timestamp":1259539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p><jats:bold>Aim\u2002<\/jats:bold> Apolipoprotein E (APOE, protein; [<jats:italic>ApoE<\/jats:italic>, gene]) is a lipid transport protein abundantly present in brain cells. We investigated whether the APOE genotype is associated with cerebral palsy (CP) and whether patients with CP with comorbid conditions and more severe neurological deficits are likely to have a particular genotype.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> In a cross\u2010sectional study, 243 individuals with spastic CP (135 males, 108 females; mean age at data collection 11 year ([SD 6y 7mo], 34% with hemiplegia, 37% with diplegia, 29% with triplegia\/tetraplegia; 44% with mild motor involvement), 31% with moderate motor involvement, 25% with severe motor involvement, were compared with healthy individuals matched by age, race, and sex to analyse the association between APOE genotype and the incidence of CP. Associations between the APOE genotype and the incidence of comorbidities and neurological deficits were studied in the group with CP.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The APOE <jats:italic>\u03b52\u03b53<\/jats:italic> genotype was significantly more prevalent in the group with CP (11%) than the comparison group (5%) (odds ratio [OR] 2.8; 95% confidence interval [CI] 1.01\u20137.66). The presence of the <jats:italic>\u03b52<\/jats:italic> allele raised the probability of having CP (OR 3.2; 95% CI 1.27\u20138.27). The presence of <jats:italic>ApoE \u03b54<\/jats:italic> was not significantly different among groups. No relation was found between APOE genotype and severity of neurological deficit or distribution of motor involvement. Four patients with CP presented the <jats:italic>\u03b54\u03b54<\/jats:italic> genotype, and all exhibited epilepsy and microcephaly. Eleven of 12 individuals with CP and macrocephaly carried the <jats:italic>\u03b53\u03b53<\/jats:italic> genotype.<\/jats:p><jats:p><jats:bold>Interpretation\u2002<\/jats:bold> A higher prevalence of the APOE <jats:italic>\u03b52<\/jats:italic> genotype was found among those with CP. The association of microcephaly and epilepsy with the <jats:italic>\u03b54\u03b54<\/jats:italic> genotype and the association of macrocephaly with <jats:italic>\u03b53<\/jats:italic> demand further investigation.<\/jats:p>","DOI":"10.1111\/j.1469-8749.2009.03465.x","type":"journal-article","created":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T17:59:51Z","timestamp":1259603991000},"page":"666-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Apolipoprotein E genotype and cerebral palsy"],"prefix":"10.1111","volume":"52","author":[{"given":"LUCIA W","family":"BRAGA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELIANA V M","family":"BORIGATO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARLOS E","family":"SPECK\u2010MARTINS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERICA U","family":"IMAMURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANA M PEDROSA","family":"GORGES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANA P","family":"IZUMI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RIZAEL C","family":"DANTAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUIS G NADAL","family":"NUNES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000218227.35560.0d"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3282f4958b"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2008.01.004"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199803090-00010"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200011000-00017"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1083"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0564-y"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S001216220500112X"},{"key":"e_1_2_7_10_2","first-page":"444","volume-title":"Mercer\u2019s Orthopaedic Surgery","author":"Campos da Paz A","year":"1994"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07414.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2671"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1542\/peds.41.1.106","article-title":"Head circumference from birth to eighteen years: practical composite international and interracial graphs","volume":"41","author":"Nellhaus D","year":"1968","journal-title":"Pediatrics"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43176-1"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471249688"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531743"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0712(03)00040-4"},{"key":"e_1_2_7_19_2","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica.Pesquisa Nacional por Amostra em Domic\u00edlios. S\u00edntese de Indicadores 2006.http:\/\/www.ibge.gov.br(accessed 11 August 2008)."},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638280500158422"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000148719.82468.CA"},{"issue":"100","key":"e_1_2_7_22_2","first-page":"26","article-title":"Apolipoprotein E genotype and outcome after traumatic brain injury in children","volume":"46","author":"Blackman JA","year":"2004","journal-title":"Dev Med Child Neurol"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2005.tb01042.x"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1469-8749.2009.03465.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1469-8749.2009.03465.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T02:42:24Z","timestamp":1698720144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1469-8749.2009.03465.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,9]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1111\/j.1469-8749.2009.03465.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1469-8749.2009.03465.x","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,9]]},"assertion":[{"value":"2010-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}