{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:30:33Z","timestamp":1778157033693,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T00:00:00Z","timestamp":1256256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>\n                    <jats:bold>Aim\u2002<\/jats:bold>\n                    The aim of this study was to explore the predictive value of quantitative assessment of hand movements in 3\u2010month\u2010old infants after neonatal stroke.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method\u2002<\/jats:bold>\n                    Thirteen infants born at term (five females, eight males; mean gestational age 39.4wks, SD 1.19, range 37\u201341wks; mean birthweight 3240g, SD 203, range 2900\u20133570g) with neonatal arterial ischaemic cerebral infarction, and 13 healthy infants (mean gestational age 39.1wks, range 37\u201341wks, SD 1.26; mean birthweight 3190g, SD 259, range 2680\u20133490g) were enrolled in the study. The absolute frequency and the asymmetry of global hand opening and closing, wrist segmental movements, and independent digit movements were assessed from videotapes recorded at around 12\u2003weeks. Neurological outcome was assessed when the infants were at least 18\u2003months old using Touwen\u2019s neurological examination.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Five of the 13 infants with neonatal stroke had normal neurological development, and eight had hemiplegia. Asymmetry of wrist segmental movements and the absolute frequency of independent digit movements were significantly different between infants with and without hemiplegia (\n                    <jats:italic>p<\/jats:italic>\n                    =0.006 and\n                    <jats:italic>p<\/jats:italic>\n                    =0.008, respectively). No differences were found in global hand movements.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Interpretation\u2002<\/jats:bold>\n                    We propose that the observed abnormalities of hand movements are the result of two different mechanisms: direct disruption of the corticospinal projection to the spinal cord, and altered modulation of the central pattern generators of general movements.\n                  <\/jats:p>","DOI":"10.1111\/j.1469-8749.2009.03497.x","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T04:41:01Z","timestamp":1256272861000},"page":"767-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Hand movements at 3\u2003months predict later hemiplegia in term infants with neonatal cerebral infarction"],"prefix":"10.1111","volume":"52","author":[{"given":"ANDREA","family":"GUZZETTA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALESSANDRA","family":"PIZZARDI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VITTORIO","family":"BELMONTI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTONIO","family":"BOLDRINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARCO","family":"CAROTENUTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIULIA","family":"D\u2019ACUNTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FABRIZIO","family":"FERRARI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SIMONA","family":"FIORI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CLAUDIO","family":"GALLO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAOLO","family":"GHIRRI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EUGENIO","family":"MERCURI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DOMENICO","family":"ROMEO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA FEDERICA","family":"ROVERSI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIOVANNI","family":"CIONI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(03)00128-3"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.1.51"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9233"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39597"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200112000-00002"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.055558"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12658-X"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-973679"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.1.39"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"e_1_2_5_12_2","volume-title":"Prechtl\u2019s Method on the Qualitative Assessment of General Movements in Preterm, Term and Young Infants","author":"Einspieler C","year":"2005"},{"key":"e_1_2_5_13_2","volume-title":"Neurological Development in Infancy","author":"Touwen BCL","year":"1976"},{"key":"e_1_2_5_14_2","first-page":"439","article-title":"Congenital hemiparesis: the spectrum of lesions. 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