{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:32:50Z","timestamp":1774438370895,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"s4","license":[{"start":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T00:00:00Z","timestamp":1316563200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>Although its cause, jaundice in the newborn, is extremely common, the disabling neurological disorder kernicterus is very rare. Kernicterus may be prevented by selecting those infants who are at risk of extreme jaundice or who may be particularly vulnerable to bilirubin neurotoxicity. Because the tools for achieving that goal are inadequate, a secondary strategy is needed. This involves a plan for emergency treatment of severely jaundiced infants, in particular those who present with neurological symptoms. In this paper I review the strategies for preventing extreme jaundice, and for reversing neurotoxicity in those infants for whom the principal strategies fail. Briefly, the tools for prevention include measurement of bilirubin while the infant is staying in the maternity unit, plotting the value on an hour\u2010specific chart, assessing other risk factors for jaundice, and educating the parents. Emergency treatment should include immediate, high\u2010irradiance phototherapy, consideration of intravenous immune globulin, and preparation for an exchange transfusion.<\/jats:p>","DOI":"10.1111\/j.1469-8749.2011.04059.x","type":"journal-article","created":{"date-parts":[[2011,9,25]],"date-time":"2011-09-25T16:20:28Z","timestamp":1316967628000},"page":"24-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Prevention of neurodevelopmental sequelae of jaundice in the newborn"],"prefix":"10.1111","volume":"53","author":[{"given":"THOR W R","family":"HANSEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,21]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.213"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.211"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.5.1075"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01409.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb00738.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211152"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.2.e15"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.297"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.105361"},{"key":"e_1_2_8_11_2","first-page":"746","article-title":"BIND \u2013 a clinical score for bilirubin induced neurologic dysfunction","volume":"104","author":"Johnson L","year":"1999","journal-title":"Pediatrics"},{"key":"e_1_2_8_12_2","first-page":"319","article-title":"Cerebral palsy in Cape Town: a comparative 12\u2010year retrospective study","volume":"53","author":"Arens LJ","year":"1978","journal-title":"S Afr Med J"},{"key":"e_1_2_8_13_2","first-page":"768","volume-title":"Avery\u2019s neonatology. 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