{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:41:49Z","timestamp":1781008909420,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>We report the cases of three children, one male and two females, with a diagnosis of early infantile Krabbe disease demonstrating intracranial calcification on computed tomography (CT). The pattern of calcification was similar in all individuals and involved the internal capsule and cerebral white matter. The presence of calcification caused some diagnostic confusion in what was otherwise a typical clinical and radiological presentation. This finding is not new and has previously been described in publications from the 1980s and 1990s reporting the CT and magnetic resonance imaging appearances of Krabbe disease. With increasing use of magnetic resonance as the first imaging modality for investigation of neurological disorders, characteristic CT appearances may be forgotten. This report serves as a reminder that Krabbe disease should be included in the differential diagnosis of disorders causing intracranial calcification.<\/jats:p>","DOI":"10.1111\/j.1469-8749.2011.04167.x","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T13:03:25Z","timestamp":1323349405000},"page":"376-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Intracranial calcification in early infantile Krabbe disease: nothing new under the sun"],"prefix":"10.1111","volume":"54","author":[{"given":"JOHN H","family":"LIVINGSTON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CLAUDIO","family":"GRAZIANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAREN","family":"PYSDEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YANICK J","family":"CROW","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SANTOSH R","family":"MORDEKAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ISABELLA","family":"MORONI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GRAZIELLA","family":"UZIEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,8]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"1164","article-title":"Infantile Krabbe disease: complementary CT and MR findings","volume":"14","author":"Choi S","year":"1993","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_3_2","first-page":"1443","article-title":"Early differential diagnosis of infantile neuronal ceroid lipofuscinosis, Rett syndrome, and Krabbe disease by CT and MR","volume":"15","author":"Vanhanen SL","year":"1994","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_4_2","first-page":"82","volume-title":"Paediatric Neuroimaging","author":"Barkovich AJ","year":"2005"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-27660-2_8"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.02062.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.66.2.302"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294356"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(91)90046-N"},{"key":"e_1_2_7_10_2","first-page":"330","volume-title":"Diseases of the Nervous System in Childhood","author":"Aicardi J","year":"2009"},{"key":"e_1_2_7_11_2","first-page":"659","volume-title":"Pediatric Neurology: Principles and Practice","author":"Pastores GM","year":"2006"},{"key":"e_1_2_7_12_2","volume-title":"The Neurology of Hereditary Metabolic Diseases of Children","author":"Lyons G","year":"2006"},{"key":"e_1_2_7_13_2","first-page":"453","article-title":"Specific CT findings in Krabbe\u2019s disease","volume":"5","author":"Kwan E","year":"1984","journal-title":"Am J Neuroradiol AJNR"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1986.tb03934.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01799484"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960503)63:1<209::AID-AJMG37>3.0.CO;2-Q"},{"key":"e_1_2_7_17_2","first-page":"206","article-title":"Early infantile and late infantile form of Krabbe disease: CT and MRI findings","volume":"29","author":"Bonetti M","year":"2007","journal-title":"Pediatr Med Chir"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243189"}],"container-title":["Developmental Medicine &amp; 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