{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:30:22Z","timestamp":1785817822318,"version":"3.56.0"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:00:00Z","timestamp":1340064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Hyperventilation\u2010induced high\u2010amplitude rhythmic slow activity with altered awareness (HIHARS) is increasingly being identified in children and is thought to be an age\u2010related non\u2010epileptic electrographic phenomenon. We retrospectively investigated the clinical outcome in 15 children (six males, nine females) with HIHARS (mean age 7y, SD 1y 11mo; range 4y 6mo\u201311y). The presenting feature in 11 cases was blank spells \u2013 two of these children also had generalized tonic\u2013clonic seizures (GTCS) \u2013 and in one individual the main concern was deteriorating school performance. Three children had symptoms suggestive of focal motor seizures. Of the nine children presenting solely with blank spells, further follow\u2010up (mean duration 18mo, SD 21mo) revealed full resolution of symptoms in six, but three had persistent symptoms. In our study, the symptoms of children with HIHARS presenting with blank spells in isolation appeared to resolve spontaneously and did not evolve into convulsive seizures or other paroxysmal events considered to be clearly epileptic. Children (with HIHARS) who presented with clinical features suggestive of GTCS or focal motor seizures (with or without blank spells) and\/or had epileptiform discharges on interictal electroencephalography were subsequently diagnosed with epilepsy.<\/jats:p>","DOI":"10.1111\/j.1469-8749.2012.04337.x","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T16:20:57Z","timestamp":1340122857000},"page":"1001-1005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Outcome of children with hyperventilation\u2010induced high\u2010amplitude rhythmic slow activity with altered awareness"],"prefix":"10.1111","volume":"54","author":[{"given":"ALEXANDER","family":"BARKER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOANNE","family":"NG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPHER D C","family":"RITTEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSALIND H","family":"KANDLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SANTOSH R","family":"MORDEKAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,19]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb01789.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb01790.x"},{"key":"e_1_2_8_4_2","first-page":"50","article-title":"Electrical activity of the brain: its relationship to the physiological states and states of impaired consciousness","volume":"19","author":"Davis H","year":"1939","journal-title":"Res Publ Assoc Nerv Ment Dis"},{"key":"e_1_2_8_5_2","first-page":"312","article-title":"Disorders of conscious awareness: hyperventilation syndrome","volume":"19","author":"Pincus JH","year":"1978","journal-title":"Br J Hosp Med"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.35101.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1988.tb03716.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X1995000200012"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(43)80252-3"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/81.3.426"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480140042004"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389000500403"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1469-8749.2012.04337.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1469-8749.2012.04337.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T23:21:49Z","timestamp":1697412109000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1469-8749.2012.04337.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,19]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1469-8749.2012.04337.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1469-8749.2012.04337.x","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,19]]},"assertion":[{"value":"2012-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}